1,3-dimethyl-5-[(1S,2E)-1,3-bis(naphth-1-yl)prop-2-en-1-yl]barbituric acid | 1224301-62-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,3-dimethyl-5-[(1S,2E)-1,3-bis(naphth-1-yl)prop-2-en-1-yl]barbituric acid
• CAS: 1224301-62-5
• 化学式: C₂₉H₂₄N₂O₃
• 分子量: 448.521
• InChiKey: INQLDRSSWGNRQM-NUOQETRUSA-N

反应信息

• 作为产物：
  描述：

  1,3-二甲基巴比妥酸 、 (E)-1,3-di(naphthalen-1-yl)allyl acetate 在 bis(η3-allyl-μ-chloropalladium(II)) 、 2,2'-bis[(S)-4-tert-butyloxazolin-2-yl]diphenylsulfide 、 potassium acetate 作用下， 以 甲苯 为溶剂， 反应 72.67h， 生成 1,3-dimethyl-5-[(1S,2E)-1,3-bis(naphth-1-yl)prop-2-en-1-yl]barbituric acid 、 1,3-dimethyl-5-[(1R,2E)-1,3-bis(naphth-1-yl)prop-2-en-1-yl]barbituric acid
  参考文献：
  名称：

  Rational tuning of the rigidity of a ligand scaffold: synthesis of diphenylsulfide-linked bis(oxazoline) ligands and their application in asymmetric allylic alkylation

  摘要：

  The scaffold rigidity of bis(oxazoline) ligands was rationally tuned on the basis of literature information. Diphenylsulfide-linked bis(oxazoline) ligands with a flexible scaffold were efficiently synthesized to test our hypothesis. The improved enantioselectivity in palladium-catalyzed asymmetric allylic alkylation reaction was achieved as we expected. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.01.015