pentamethyl 2-cyclopropyl-5-hydroxy-1-oxo-1,2-dihydroisoquinoline-3,4,6,7,8-pentacarboxylate | 1234789-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: pentamethyl 2-cyclopropyl-5-hydroxy-1-oxo-1,2-dihydroisoquinoline-3,4,6,7,8-pentacarboxylate
• CAS: 1234789-70-8
• 化学式: C₂₂H₂₁NO₁₂
• 分子量: 491.408
• InChiKey: LTGRWTLGFGHRMJ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 pentamethyl 2-cyclopropyl-5-hydroxy-1-oxo-1,2-dihydroisoquinoline-3,4,6,7,8-pentacarboxylate 以 乙醚 、 二氯甲烷 为溶剂， 以100%的产率得到2-cyclopropyl-3,4,6,7,8-penta(methoxycarbonyl)-1-oxo-5-methoxy-1,2-dihydroisoquinoline
  参考文献：
  名称：

  Synthesis of substituted 2-alkyl-5-hydroxy-1-oxo-1,2-dihydroisoquinolines and their new condensed structures

  摘要：

  Original methods were developed for the synthesis of 1,2-dihydroisoquinoline derivatives by means of the cyclization of N-substituted hexamethoxycarbonyl-3-propenylpyridin-2-ones either upon action of bases or directly by reaction of hepta(methoxycarbonyl)cycloheptatrienyl potassium with primary amines.

  DOI：

  10.1016/j.mencom.2010.03.006
• 作为产物：
  描述：

  potassium 2-cyclopropyl-3,4,6,7,8-penta(methoxycarbonyl)-1-oxo-1,2-dihydroisoquinolin-5-oate 在 硫酸 、 水 作用下， 生成 pentamethyl 2-cyclopropyl-5-hydroxy-1-oxo-1,2-dihydroisoquinoline-3,4,6,7,8-pentacarboxylate
  参考文献：
  名称：

  Synthesis of substituted 2-alkyl-5-hydroxy-1-oxo-1,2-dihydroisoquinolines and their new condensed structures

  摘要：

  Original methods were developed for the synthesis of 1,2-dihydroisoquinoline derivatives by means of the cyclization of N-substituted hexamethoxycarbonyl-3-propenylpyridin-2-ones either upon action of bases or directly by reaction of hepta(methoxycarbonyl)cycloheptatrienyl potassium with primary amines.

  DOI：

  10.1016/j.mencom.2010.03.006