(S)-5-benzyl-4-isopropyl-2-(1-methoxynaphthalen-2-yl)-5,6-dihydro-4H-1,3,4-oxadiazine | 1261297-89-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-5-benzyl-4-isopropyl-2-(1-methoxynaphthalen-2-yl)-5,6-dihydro-4H-1,3,4-oxadiazine
• CAS: 1261297-89-5
• 化学式: C₂₄H₂₆N₂O₂
• 分子量: 374.483
• InChiKey: AYRPIYNFDJJTOL-FQEVSTJZSA-N

反应信息

• 作为反应物：
  描述：

  (S)-5-benzyl-4-isopropyl-2-(1-methoxynaphthalen-2-yl)-5,6-dihydro-4H-1,3,4-oxadiazine 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以74%的产率得到(S)-2-(5-benzyl-4-isopropyl-5,6-dihydro-4H-1,3,4-oxadiazin-2-yl)naphthalen-1-ol
  参考文献：
  名称：

  Synthesis and application of oxadiazines as chiral ligands for the enantioselective addition of diethylzinc to aldehydes

  摘要：

  A series of oxadiazines derived from L-phenylalanine bearing phenolic substituents have been synthesized in a multistep one pot process This process involves the reaction of a mixed anhydride with a beta-hydrazino alcohol methanesulfonylation of the alcohol moiety and base induced cyclization The resultant oxadiazines were employed in the asymmetric addition of diethylzinc to aldehydes (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetasy.2010.09.010
• 作为产物：
  描述：

  在 甲基磺酰氯 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 生成 (S)-5-benzyl-4-isopropyl-2-(1-methoxynaphthalen-2-yl)-5,6-dihydro-4H-1,3,4-oxadiazine
  参考文献：
  名称：

  Synthesis and application of oxadiazines as chiral ligands for the enantioselective addition of diethylzinc to aldehydes

  摘要：

  A series of oxadiazines derived from L-phenylalanine bearing phenolic substituents have been synthesized in a multistep one pot process This process involves the reaction of a mixed anhydride with a beta-hydrazino alcohol methanesulfonylation of the alcohol moiety and base induced cyclization The resultant oxadiazines were employed in the asymmetric addition of diethylzinc to aldehydes (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetasy.2010.09.010