(E)-1-(3-(6-methoxynaphth-2-yl)but-2-enyl)piperidine hydrochloride | 1219009-27-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (E)-1-(3-(6-methoxynaphth-2-yl)but-2-enyl)piperidine hydrochloride
• CAS: 1219009-27-4
• 化学式: C₂₀H₂₅NO*ClH
• 分子量: 331.886
• InChiKey: OUXRMFYQILIOCE-QFHYWFJHSA-N

反应信息

• 作为反应物：
  描述：

  (E)-1-(3-(6-methoxynaphth-2-yl)but-2-enyl)piperidine hydrochloride 在 氢气 作用下， 以 乙醇 为溶剂， 以63%的产率得到rac-1-(3-(6-methoxynaphth-2-yl)butyl)piperidine
  参考文献：
  名称：

  Design, synthesis and SAR analysis of novel selective σ1 ligands (Part 2)

  摘要：

  In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma(1)- and sigma(2)-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at mu-opioid, delta-opioid and kappa-opioid receptors. Biological results are herein presented and discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.12.039
• 作为产物：
  描述：

  1-(3-(6-methoxynaphth-2-yl)but-2-enyl)piperidine 在 盐酸 作用下， 以 水 为溶剂， 生成 (E)-1-(3-(6-methoxynaphth-2-yl)but-2-enyl)piperidine hydrochloride
  参考文献：
  名称：

  Design, synthesis and SAR analysis of novel selective σ1 ligands (Part 2)

  摘要：

  In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma(1)- and sigma(2)-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at mu-opioid, delta-opioid and kappa-opioid receptors. Biological results are herein presented and discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.12.039