| 1220285-56-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1220285-56-2
• 化学式: C₁₃H₁₆N₂Si
• 分子量: 228.369
• InChiKey: JYMJVNQYEGLAMS-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以92%的产率得到2-(4-amino-3-(1-ethynyl)phenyl)acetonitrile
  参考文献：
  名称：

  Gold(I)-catalyzed one-pot reaction between 2-alkynylanilines and alkynols leading to the formation of C-3-substituted indoles: a case of formal carboamination of alkynes

  摘要：

  A process involving gold(I)-catalyzed formal carboamination of alkynes for the synthesis of C-3-substituted indoles has been developed. The procedure utilizes easily accessible starting materials such as 2-alkynylanilines and alkynols. A series of C-3-functionalized indoles are accessible by using this one-pot strategy. Mechanistically, the reaction involves three catalytic cycles and each of them is essentially catalyzed by a single metal catalyst, that is, Ph3PAuOTf. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.01.036
• 作为产物：
  描述：

  2-(4-amino-3-iodophenyl)acetonitrile 、 三甲基乙炔基硅 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 以81%的产率得到
  参考文献：
  名称：

  Gold(I)-catalyzed one-pot reaction between 2-alkynylanilines and alkynols leading to the formation of C-3-substituted indoles: a case of formal carboamination of alkynes

  摘要：

  A process involving gold(I)-catalyzed formal carboamination of alkynes for the synthesis of C-3-substituted indoles has been developed. The procedure utilizes easily accessible starting materials such as 2-alkynylanilines and alkynols. A series of C-3-functionalized indoles are accessible by using this one-pot strategy. Mechanistically, the reaction involves three catalytic cycles and each of them is essentially catalyzed by a single metal catalyst, that is, Ph3PAuOTf. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.01.036