| 1194063-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• CAS: 1194063-29-0
• 化学式: C₁₆H₂₆N₄O₄
• 分子量: 338.407
• InChiKey: ZLMULZSCYVKAFW-LBPRGKRZSA-N

反应信息

• 作为反应物：
  描述：

  邻氯苯酚 、 在 偶氮二甲酸二叔丁酯 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of pyridazinone-based 5-HT2C agonists

  摘要：

  The SAR of a series of pyridazinone derived 5-HT2C agonists has been explored and resulted in identification of a compound with excellent levels of 5-HT2C functional agonism and selectivity over 5-HT2A and 5-HT2B. This compound displayed good in vivo efficacy in pre-clinical models of stress urinary incontinence, despite having physiochemical properties commensurate with impaired CNS penetration. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.136
• 作为产物：
  描述：

  在 二异丁基氢化铝 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of pyridazinone-based 5-HT2C agonists

  摘要：

  The SAR of a series of pyridazinone derived 5-HT2C agonists has been explored and resulted in identification of a compound with excellent levels of 5-HT2C functional agonism and selectivity over 5-HT2A and 5-HT2B. This compound displayed good in vivo efficacy in pre-clinical models of stress urinary incontinence, despite having physiochemical properties commensurate with impaired CNS penetration. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.136