| 1190874-37-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• CAS: 1190874-37-3
• 化学式: C₁₅H₂₃ClN₄O₂
• 分子量: 326.826
• InChiKey: JRPJZXWBKQRBHV-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 bromomethyl-ortho-nitrophenyl linked Tentagel resin 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 tert-butyl 4-[3-chloro-5-(methylsulfonyloxymethyl)-2-pyridyl]piperazine-1-carboxylate
  参考文献：
  名称：

  Novel CXCR3 antagonists with a piperazinyl-piperidine core

  摘要：

  High-throughput screening of an encoded combinatorial aryl piperazine library led to the identification of a novel series of potent piperazinyl-piperidine based CXCR3 antagonists. Analogs of the initial hit were synthesized via solid and solution phase methods to probe the influence of structure on the CXCR3 binding of these molecules. Various functional groups were found to contribute to the overall potency and essential molecular features were identified. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.020
• 作为产物：
  描述：

  在 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Novel CXCR3 antagonists with a piperazinyl-piperidine core

  摘要：

  High-throughput screening of an encoded combinatorial aryl piperazine library led to the identification of a novel series of potent piperazinyl-piperidine based CXCR3 antagonists. Analogs of the initial hit were synthesized via solid and solution phase methods to probe the influence of structure on the CXCR3 binding of these molecules. Various functional groups were found to contribute to the overall potency and essential molecular features were identified. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.020