| 1174193-23-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1174193-23-7
• 化学式: C₃₁H₂₅BrN₂O₂
• 分子量: 537.456
• InChiKey: QXJLPZCBVLQSOY-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 potassium phosphate 、 (R)-MOP 、 palladium diacetate 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以79%的产率得到
  参考文献：
  名称：

  Desymmetrization of malonamides via an enantioselective intramolecular Buchwald–Hartwig reaction

  摘要：

  A new form of enantioselective nitrogen arylation reaction is described. Beginning with symmetrical alpha-(2-bromobenzyl)malonamides, intramolecular palladium-catalyzed cross-coupling using a catalyst system including 3.3 mol % Pd(OAc)(2) and 6.6 mol % of the chiral biaryl monophosphine (R)-MOP, desymmetrized quinolinone products are obtained in nearly quantitative yields in enantiomeric ratios up to 88:12. This Letter represents a rare example of enantioselective Buchwald-Hartwig reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.133