3,4-acenaphthoquino-6-hydrazino-5-nitro-1,4-dihydro-4-pyridazinol | 1431790-26-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3,4-acenaphthoquino-6-hydrazino-5-nitro-1,4-dihydro-4-pyridazinol
• CAS: 1431790-26-9
• 化学式: C₁₄H₁₁N₅O₃
• 分子量: 297.273
• InChiKey: RTVXECRBOQGHJP-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  1,1‐dihydrazino‐2‐nitroethylene 、 苊醌 以 乙醇 为溶剂， 反应 8.0h， 生成 3,4-acenaphthoquino-6-hydrazino-5-nitro-1,4-dihydro-4-pyridazinol
  参考文献：
  名称：

  Uncatalyzed One-Pot Synthesis of Highly Substituted Pyridazines and Pyrazoline-Spirooxindoles via Domino SN/Condensation/Aza-ene Addition Cyclization Reaction Sequence

  摘要：

  A previously unknown class of highly substituted pyridazines and pyrazoline-spirooxinoles are easily prepared by an uncatalyzed one-pot three-component approach incorporating a domino SN/condensation/aza-ene addition cyclization reaction sequence. 1,1-Dihydrazino-2-nitroethylene (DHNE) which is generated in situ from the nudeophilic substitution (SN) reaction of hydrazine and 1,1-bis(methylthio)-2-nitroethylene (BMTNE), allowed to be condensed with active 1,2-dicarbonyl compounds followed by an intramolecular aza-ene addition cyclization to obtain the titled products depending on the type of 1,2-dicarbonyl. All reactions are easily performed and proceed with high efficiency under very simple and mild conditions without any catalyst and give good yields avoiding time-consuming, costly syntheses, and tedious workup and purification of products.

  DOI：

  10.1021/co400005y