| 1265111-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1265111-28-1
• 化学式: C₂₃H₂₈BNO₃
• 分子量: 377.291
• InChiKey: LPWLVCPEAHKKBL-WQNPHJJHSA-N

反应信息

• 作为反应物：
  描述：

  在 potassium hydrogen bifluoride 、 三甲基氯硅烷 、 水 作用下， 以 甲醇 、 乙腈 为溶剂， 生成 (S)-1-(Naphthalene-2-carboxamido)ethaneboronic acid
  参考文献：
  名称：

  Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors

  摘要：

  Following from the evaluation of different types of electrophiles, combined modeling and crystallographic analyses are used to generate potent boronic acid based inhibitors of a penicillin binding protein. The results suggest that a structurally informed approach to penicillin binding protein inhibition will be useful for the development of both improved reversibly binding inhibitors, including boronic acids, and acylating inhibitors, such as beta-lactams.

  DOI：

  10.1021/ml100260x