| 1194714-54-9

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 麦角林及其衍生物
• CAS: 1194714-54-9
• 化学式: C₁₅H₁₄N₂O₂
• 分子量: 254.288
• InChiKey: PGAXNCJUCMSWLK-DGCLKSJQSA-N

物化性质

• 熔点：
  243-245 °C (decomp)
• 沸点：
  557.0±50.0 °C(Predicted)
• 密度：
  1.393±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 氢气 作用下， 生成 ergoline-8-carboxylic acid
  参考文献：
  名称：

  Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst1 receptor

  摘要：

  Non-peptidic compounds containing the octahydro-indolo[4,3-fg]quinoline (ergoline) structural element have been optimized into derivatives with high affinity (pK(d) r sst(1) > 9) and selectivity (> 1000-fold for h sst(1) over h sst(2)-h sst(5)) for the somatostatin sst(1) receptor. In functional assays, these ergolines act as antagonists at human recombinant sst(1) receptors. Pharmacokinetic studies in rodents reveal good oral bioavailability and brain penetration for some of these compounds. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.030