| 1019339-51-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• CAS: 1019339-51-5
• 化学式: C₂₃H₂₆N₄O₅S₂
• 分子量: 502.615
• InChiKey: MSZMUUSAHUBMEI-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents

  摘要：

  5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The structure-activity relationship (SAR) associated with variation of the pyridazinone 2- and 6-substituents is discussed. The synthesis and metabolic stability of this new class of compounds are also described. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.005