bis-(9H-fluoren-9-ylmethyl) (1S,2S,3R)-3-hydroxy-2-methyl-1-[(S)-3-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-butyl]-5-trimethylsilanyl-pent-4-ynylphosphate | 1044739-40-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: bis-(9H-fluoren-9-ylmethyl) (1S,2S,3R)-3-hydroxy-2-methyl-1-[(S)-3-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-butyl]-5-trimethylsilanyl-pent-4-ynylphosphate
• CAS: 1044739-40-3
• 化学式: C₄₇H₅₃O₇PSi
• 分子量: 788.993
• InChiKey: BUGVNZUPPQYBKV-ZTIUSEBTSA-N

反应信息

• 作为产物：
  描述：

  bis-(9H-fluoren-9-ylmethyl) (2S,3R)-3-(tert-butyldimethylsilanyloxy)-2-methyl-1-[(S)-3-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-butyl]-5-trimethylsilanylpent-4-ynylphosphate 在 吡啶 、 氢氟酸 作用下， 以 四氢呋喃 为溶剂， 反应 21.0h， 生成 bis-(9H-fluoren-9-ylmethyl) (1R,2S,3R)-3-hydroxy-2-methyl-1-[(S)-3-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-butyl]-5-trimethylsilanyl-pent-4-ynylphosphate 、 bis-(9H-fluoren-9-ylmethyl) (1S,2S,3R)-3-hydroxy-2-methyl-1-[(S)-3-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-butyl]-5-trimethylsilanyl-pent-4-ynylphosphate
  参考文献：
  名称：

  Synthetic studies toward cytostatin, a natural product inhibitor of protein phosphatase 2A

  摘要：

  Synthetic approaches toward the natural product cytostatin, an inhibitor of protein phosphatase 2A possessing cytotoxic and antimetastatic activities, have been investigated. A formal synthesis of cytostatin has been achieved according to a strategy relying on the formation of the C8-C9 bond by a nucleophilic addition of a functionalized organolithium (C1-C8 subunit) to an aldehyde (C9-C13 subunit). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.012