[1]naphthyl-amidophosphoryl chloride | 103754-37-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [1]naphthyl-amidophosphoryl chloride
• CAS: 103754-37-6
• 化学式: C₁₀H₈Cl₂NOP
• 分子量: 260.059
• InChiKey: QKGVKCZZJGVOFQ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  [1]naphthyl-amidophosphoryl chloride 在 氨 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 生成 N-(α-naphthyl)phosphoric triamide
  参考文献：
  名称：

  Design, Synthesis, and Biological Evaluation of Phosphoramide Derivatives as Urease Inhibitors

  摘要：

  The design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors to reduce the loss of ammonia has been carried out. Forty phosphorus derivatives were synthesized and their inhibitory activities evaluated against that of jack bean urease. In addition, in vivo assays have been carried out. All of the compounds were characterized by IR, H-1 NMR, MS, and elemental microanalysis. In some cases, detailed molecular modeling studies were carried out, and these highlighted the interaction between the enzyme active center and the compounds and also the characteristics related to their activity as urease inhibitors. According to the IC50 values for in vitro inhibitory activity, 12 compounds showed values below 1 mu M and 8 of them represent improvements of activity in comparison to the commercial urease inhibitor N-n-butylthiophosphorictriamide (NBPT) (100 nM) (AGROTAIN). On the basis of the activity results and the conclusions of the molecular modeling study, a structural model for new potential inhibitors has been defined.

  DOI：

  10.1021/jf072901y
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 三氯氧磷 作用下， 生成 [1]naphthyl-amidophosphoryl chloride
  参考文献：
  名称：

  Li; Chang, Huaxue Xuebao/Acta Chimica Sinica, 1957, vol. 23, p. 99,101

  摘要：

  DOI：