| 1355220-39-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1355220-39-1
• 化学式: C₁₆H₁₄FNO₄
• 分子量: 303.29
• InChiKey: LMYAKDZJCULECJ-ZDUSSCGKSA-N

物化性质

• 沸点：
  612.0±50.0 °C(Predicted)
• 密度：
  1.333±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸酐 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以80%的产率得到3a-fluoromethyl-2-naphthalen-1-yl-6,6a-dihydro-3aH-furo[3,2-d]oxazol-5-one
  参考文献：
  名称：

  Synthesis and evaluation of novel prodrugs of caspase inhibitors

  摘要：

  A novel type of caspase inhibitor prodrug that improves systemic exposure after oral administration in rats has been designed. Such a prodrug, based on a 6,6a-dihydrofuro[3,2-d]oxazol-5(3aH)-one motif, has the advantage of rapidly liberating the active inhibitor without producing any cleavage by-product. Prodrugs 6-8, are synthesised in a high yielding one-step transformation from the active parents with high diastereomeric excess. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.102