(Z)-4-ethylidene-3-(furan-2-yl)-1,2,5-thiadiazoline-1,1-dioxide | 1421479-15-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: (Z)-4-ethylidene-3-(furan-2-yl)-1,2,5-thiadiazoline-1,1-dioxide
• CAS: 1421479-15-3
• 化学式: C₈H₈N₂O₃S
• 分子量: 212.229
• InChiKey: FSHBIZIIAGTUNB-KXFIGUGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.82
• 重原子数：
  14.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  71.67
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (Z)-4-ethylidene-3-(furan-2-yl)-1,2,5-thiadiazoline-1,1-dioxide 在 [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I) 、 甲酸 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 50.0h， 以85%的产率得到(S)-4-ethyl-3-(furan-2-yl)-4,5-dihydro-1,2,5-thiadiazoline-1,1-dioxide
  参考文献：
  名称：

  Enantioselective Synthesis of 3,4-Disubstituted cis- and trans-1,2,5-Thiadiazolidine-1,1-dioxides as Precursors for Chiral 1,2-Diamines

  摘要：

  Both, cis- and trans-3,4-disubstituted thiadiazolidines 5 and 6 can enantioselectively be obtained from thiadiazoles 2 which, in turn, are efficiently prepared from the respective 1,2-diketone by an improved protocol. An asymmetric ruthenium-catalyzed transfer hydrogenation followed by a diastereoselective hydride addition furnishes exclusively the cis-isomers 5 which, under acidic conditions, undergo a novel isomerization into the trans-isomers 6. These cyclic sulfamides can be transformed into 1,2-diamines as well as 2,3-diamino acids.

  DOI：

  10.1021/ol3034753
• 作为产物：
  描述：

  糠醛 在 N,N'-bis(trimethylsilyl)sulfamide 、 三氟化硼乙醚 、 3,4-二甲基-5-(2-羟乙基)碘代噻唑 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 8.0h， 生成 (Z)-4-ethylidene-3-(furan-2-yl)-1,2,5-thiadiazoline-1,1-dioxide
  参考文献：
  名称：

  Enantioselective Synthesis of 3,4-Disubstituted cis- and trans-1,2,5-Thiadiazolidine-1,1-dioxides as Precursors for Chiral 1,2-Diamines

  摘要：

  Both, cis- and trans-3,4-disubstituted thiadiazolidines 5 and 6 can enantioselectively be obtained from thiadiazoles 2 which, in turn, are efficiently prepared from the respective 1,2-diketone by an improved protocol. An asymmetric ruthenium-catalyzed transfer hydrogenation followed by a diastereoselective hydride addition furnishes exclusively the cis-isomers 5 which, under acidic conditions, undergo a novel isomerization into the trans-isomers 6. These cyclic sulfamides can be transformed into 1,2-diamines as well as 2,3-diamino acids.

  DOI：

  10.1021/ol3034753