Zn(N'-(2-hydroxynaphthalenemethylene)-4-(2-hydroxynaphthalenemethylenamine)benzoylhydrazine(1-)) | 1247019-22-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Zn(N'-(2-hydroxynaphthalenemethylene)-4-(2-hydroxynaphthalenemethylenamine)benzoylhydrazine(1-))
• CAS: 1247019-22-2
• 化学式: C₂₉H₂₀N₃O₃Zn
• 分子量: 523.886
• InChiKey: DXUQOHHQQXSTME-XFWVDBPTSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  zinc(II) perchlorate 、 N'-(2-hydroxynaphthalenemethylene)-4-(2-hydroxynaphthalenemethylenamine)benzoylhydrazine 以 二甲基亚砜 为溶剂， 生成 Zn(N'-(2-hydroxynaphthalenemethylene)-4-(2-hydroxynaphthalenemethylenamine)benzoylhydrazine(1-))
  参考文献：
  名称：

  Study of the interaction between a new Schiff-base complex and bovine serum albumin by fluorescence spectroscopy

  摘要：

  A new Schiff-base compound, N'-(2-hydroxynaphthalenemethylene)-4-(2-hydroxyl naphthalenemethylenamine)benzoylhydrazine (1), was synthesized and the interaction between zinc complex (1-Zn) and bovine serum albumin (BSA) was investigated by fluorescence and absorption spectroscopies. A marked increase in the fluorescence intensity of 1-Zn was observed at 475 nm upon addition of BSA when excitation wavelength was set at 370 nm in pH 7.4 Tris-HCl buffer solution. Reversely, the intrinsic fluorescence of BSA could be quenched by 1-Zn complex. The quenching mechanism was suggested as static quenching according to the Stern-Volmer equation and the UV-vis absorption spectral change of 1-Zn upon addition of BSA. The binding constants K-b and the number of binding sites n were calculated. The effect of 1-Zn on the conformation of BSA was studied using synchronous fluorescence spectroscopy and three-dimensional fluorescence spectroscopy. In addition, the binding average distance r between the donor (BSA) and acceptor (1-Zn) was estimated based on the Forster's non-radiation energy transfer theory. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2010.06.010