(Z)-3,7-Dimethyl-10-(naphthalen-1-ylamino)-dec-6-en-1-ol | 263012-49-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (Z)-3,7-Dimethyl-10-(naphthalen-1-ylamino)-dec-6-en-1-ol
• CAS: 263012-49-3
• 化学式: C₂₂H₃₁NO
• 分子量: 325.494
• InChiKey: UMYMJSHRRNNMPJ-LSCVHKIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.78
• 重原子数：
  24.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.26
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (Z)-3,7-Dimethyl-10-(naphthalen-1-ylamino)-dec-6-en-1-ol 在 四丁基磷酸氢铵 、 三氯乙腈 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以70%的产率得到Phosphoric acid mono-[(Z)-3,7-dimethyl-10-(naphthalen-1-ylamino)-dec-6-enyl] ester
  参考文献：
  名称：

  Synthesis of dolichyl phosphate derivatives with fluorescent label at the ω-end of the chain, new tools to study protein glycosylation

  摘要：

  Derivatives of dolichyl phosphate (Dol-P) with 2-aminopyridine or 1-aminonaphtalene fluorophore groups at the omega-end of the chain were synthesized. These products serve as substrates for recombinant yeast Dol-P-mannose synthase. Fluorescence resonance energy transfer between a Trp residue of the enzyme and the 1-aminonaphtalene group of the Dol-P analogue was demonstrated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00662-9
• 作为产物：
  描述：

  10-acetoxy-4,8-dimethyldec-4Z-en-1-al 在 3 A molecular sieve 、 potassium carbonate 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 4.5h， 生成 (Z)-3,7-Dimethyl-10-(naphthalen-1-ylamino)-dec-6-en-1-ol
  参考文献：
  名称：

  Synthesis of dolichyl phosphate derivatives with fluorescent label at the ω-end of the chain, new tools to study protein glycosylation

  摘要：

  Derivatives of dolichyl phosphate (Dol-P) with 2-aminopyridine or 1-aminonaphtalene fluorophore groups at the omega-end of the chain were synthesized. These products serve as substrates for recombinant yeast Dol-P-mannose synthase. Fluorescence resonance energy transfer between a Trp residue of the enzyme and the 1-aminonaphtalene group of the Dol-P analogue was demonstrated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00662-9