| 1401522-35-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• CAS: 1401522-35-7
• 化学式: C₁₀H₁₁O₃*K
• 分子量: 218.294
• InChiKey: KZFLEKRGWRMISS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.62
• 重原子数：
  14.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.36
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  、 2-(4-acetoxybenzyl) isoindoline-1,3-dione 在 水 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以76%的产率得到
  参考文献：
  名称：

  Photodecarboxylative addition of carboxylates to phthalimides: a concise access to biologically active 3-(alkyl and aryl)methylene-1H-isoindolin-1-ones

  摘要：

  A series of 3-(alkyl and aryl)methyleneisoindolin-1-one derivatives were synthesized in a simple two-step procedure using a recently established photodecarboxylative addition of carboxylates to phthalimides as the key-step. Subsequent acid-catalyzed dehydration and deprotection furnished the desired target compounds with high E-selectivity. The reaction sequence was applied to the synthesis of the known bioactive phenylethylene derivative, AKS-186. Different analogues, including heteroatom-containing isosteres were also synthesized using this approach. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.142