di(7-hydroxy-2-naphthyl)disulfide | 945263-76-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: di(7-hydroxy-2-naphthyl)disulfide
• 英文别名: 7,7'-disulfanediyl-di-[2]naphthol；Bis-(7-hydroxy-naphthyl-(2))-disulfid；7,7'-Disulfandiyl-di-[2]naphthol
• CAS: 945263-76-3
• 化学式: C₂₀H₁₄O₂S₂
• 分子量: 350.462
• InChiKey: ISZNYRYPAPKOJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.46
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  di(7-hydroxy-2-naphthyl)disulfide 、 三甲基乙酸酐 生成
  参考文献：
  名称：

  Effects of oxygen–sulfur substitution on glycosaminoglycan-priming naphthoxylosides

  摘要：

  Three series of sulfur-containing analogs to the selectively antiproliferative 2-(6-hydroxynaphthyl) beta-D-xylopyranoside were synthesized and their biological properties investigated. A short, general route to hydroxynaphthyl disulfides from dihydroxy-naphthalenes was developed to utilize the disulfide bond as a sulfur-selective protecting group to enable the orthogonal protection of hydroxyls and thiols. The results indicate that hydrophobic, uncharged oxygen-sulfur substituted naphthoxylosides are taken up by calls and initiate priming of GAG chains to a greater extent compared to the oxygen analogs. No correlation between priming ability and antiproliferative activity was observed. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.05.008
• 作为产物：
  描述：

  7-hydroxy-2-mercaptonaphthalene 在 碘 作用下， 以 甲醇 、 水 为溶剂， 生成 di(7-hydroxy-2-naphthyl)disulfide
  参考文献：
  名称：

  Effects of oxygen–sulfur substitution on glycosaminoglycan-priming naphthoxylosides

  摘要：

  Three series of sulfur-containing analogs to the selectively antiproliferative 2-(6-hydroxynaphthyl) beta-D-xylopyranoside were synthesized and their biological properties investigated. A short, general route to hydroxynaphthyl disulfides from dihydroxy-naphthalenes was developed to utilize the disulfide bond as a sulfur-selective protecting group to enable the orthogonal protection of hydroxyls and thiols. The results indicate that hydrophobic, uncharged oxygen-sulfur substituted naphthoxylosides are taken up by calls and initiate priming of GAG chains to a greater extent compared to the oxygen analogs. No correlation between priming ability and antiproliferative activity was observed. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.05.008

文献信息

• Martens Hardness HM — an international accepted designation for “Hardness under Test Force”
  作者：H.-R. Wilde、A. Wehrstedt

  DOI：10.1002/1521-4052(200010)31:10<937::aid-mawe937>3.0.co;2-1

  日期：2000.10