| 1268036-25-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• CAS: 1268036-25-4
• 化学式: C₁₆H₃₅N₅O₂
• 分子量: 329.486
• InChiKey: IPHHZAHWKUONOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.01
• 重原子数：
  23.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  77.66
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  在 sodium carbonate 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 28.0h， 生成
  参考文献：
  名称：

  PET Imaging and Biodistribution of Silicon Quantum Dots in Mice

  摘要：

  Investigation of nanomaterial disposition and fate in the body is critical before such material can be translated into clinical application. Herein a new macrocyclic ligand (64)Cu(2+) complex was synthesized and used to label dextran-coated silicon quantum dots (QD), with an average hydrodynamic diameter of 15.1 +/- 7.6 nm. The chelate showed exceptional stability demonstrated by no loss radiolabel under a ligand competion reaction with EDTA. The QDs biodistribution in mice was quantitatively evaluted by in vivo positron mission tomography (PET) imaging and ex vivo gamma counting. Results showed that they were excreted via renal filtratin shortly postinjection and also accumulated in the liver.

  DOI：

  10.1021/ml1002844
• 作为产物：
  描述：

  在 caesium carbonate 作用下， 生成
  参考文献：
  名称：

  Straightforward and mild deprotection methods of N-mono- and N,N-functionalised bisaminal cyclens

  摘要：

  Strategic removal of the bisaminal bridge of N-mono- and N-1,N-7-difunctionalised cyclen glyoxal derivatives was carried out via transamination processes with vicinal diamines. These procedures were found to be particularly well-suited for cyclen targets bearing sensitive groups. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.04.021