[8-(2-Hydroxy-phenyl)-octyl]-carbamic acid tert-butyl ester | 141920-34-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: [8-(2-Hydroxy-phenyl)-octyl]-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[8-(2-hydroxyphenyl)octyl]carbamate
• CAS: 141920-34-5
• 化学式: C₁₉H₃₁NO₃
• 分子量: 321.46
• InChiKey: WVYOWQKEIFULBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [8-(2-Hydroxy-phenyl)-octyl]-carbamic acid tert-butyl ester 在 四甲基乙二胺 、 三氟化硼乙醚 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 Acetic acid (4Z,6E,19Z,21E)-22-acetoxy-2,17-dioxo-1,16-diaza-cyclotriaconta-4,6,19,21-tetraen-7-yl ester
  参考文献：
  名称：

  Photolactamization: A Novel Synthetic Entry into Large Ring-Sized Lactams

  摘要：

  Diene ketenes smoothly accessible by photochemical ring cleavage of omicron-quinol acetates, in the presence of primary or secondary amines afford the corresponding amides. In an intramolecular version of this reaction macrocyclic lactams of type A are produced, if aminoalkylated omicron-quinol acetates of type C are used as photo reactants. These photo reactants are available on acid mediated removal of the Boc-protecting group from Wessely acetoxylation products of type D, easily formed via compounds of type E from aminoalkylated phenols of type F.

  DOI：

  10.1016/0040-4039(92)88118-o
• 作为产物：
  描述：

  Methanesulfonic acid 7-(2-hydroxy-phenyl)-heptyl ester 在 lithium aluminium tetrahydride 作用下， 生成 [8-(2-Hydroxy-phenyl)-octyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Photolactamization: A Novel Synthetic Entry into Large Ring-Sized Lactams

  摘要：

  Diene ketenes smoothly accessible by photochemical ring cleavage of omicron-quinol acetates, in the presence of primary or secondary amines afford the corresponding amides. In an intramolecular version of this reaction macrocyclic lactams of type A are produced, if aminoalkylated omicron-quinol acetates of type C are used as photo reactants. These photo reactants are available on acid mediated removal of the Boc-protecting group from Wessely acetoxylation products of type D, easily formed via compounds of type E from aminoalkylated phenols of type F.

  DOI：

  10.1016/0040-4039(92)88118-o