6-amino-1,3-dimethyl-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one | 80082-05-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 6-amino-1,3-dimethyl-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one
• 英文别名: 6-Amino-1,3-dimethyl-1H-pyrazolo{3,4-d}pyrimidin-4(5H)-one；6-Amino-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-ol；6-amino-1,3-dimethyl-5H-pyrazolo[3,4-d]pyrimidin-4-one
• CAS: 80082-05-9
• 化学式: C₇H₉N₅O
• mdl: MFCD20545708
• 分子量: 179.181
• InChiKey: MGGQQOLWYPIKFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  85.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-(1-methylhydrazino)isocytosine 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 50.0h， 生成 6-amino-1,3-dimethyl-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one
  参考文献：
  名称：

  Pyrimido[4,5-c]pyridazines. 3. Preferential formation of 8-amino-1H-pyrimido[4,5-c]-1,2-diazepin-6(7H)-ones by cyclizations with .alpha.,.gamma.-dioxo esters

  摘要：

  DOI：

  10.1021/jo00343a013

文献信息

• 1H-Pyrimido[4,5-c]-1,2-diazepines
  申请人：Burroughs Wellcome Co.

  公开号：US04235905A1

  公开（公告）日：1980-11-25

  Compounds of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from a lower alkyl group, a phenyl group (optionally substituted by one or more hydroxy or lower alkoxy groups), a pyridyl group or a group --CO.sub.2 R where R is a lower alkyl group, (provided that when R.sup.1 is a group --CO.sub.2 R, R.sup.2 is a lower alkyl group) are disclosed. The compounds of formula (I) are useful as intermediates to compounds of other ring systems which are of pharmacological interest. Certain of the compounds of formula (I) are also useful as antimicrobial agents.

  通式（I）的化合物如下：##STR1##其中R.sup.1和R.sup.2选自较低的烷基，苯基（可选地被一个或多个羟基或较低的烷氧基取代），吡啶基或一个羧基 --CO.sub.2 R，其中R是一个较低的烷基（但当R.sup.1是羧基 --CO.sub.2 R时，R.sup.2必须是较低的烷基）。该通式（I）的化合物可用作其他药理学感兴趣的环系统的中间体。其中某些通式（I）的化合物也可用作抗微生物剂。
• 2,7-Diamino-8-methyl-5-substituted pyrido{2,3-d}pyrimidin-6-ones
  申请人：Burroughs Wellcome Co.

  公开号：US04237289A1

  公开（公告）日：1980-12-02

  Compounds of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from a lower alkyl group, a phenyl group (optionally substituted by one or more hydroxy or lower alkoxy groups), a pyridyl group or a group --CO.sub.2 R where R is a lower alkyl group, (provided that when R.sup.1 is a group --CO.sub.2 R, R.sup.2 is a lower alkyl group) are disclosed. The compounds of formula (I) are useful as intermediates to compounds of other ring systems which are of pharmacological interest. Certain of the compounds of formula (I) are also useful as antimicrobial agents.

  一般公式(I)的化合物如下所示：##STR1##其中R.sup.1和R.sup.2选择自下列一种：较低的烷基，苯基（可选地被一个或多个羟基或较低的烷氧基替代），吡啶基或基团--CO.sub.2R，其中R是较低的烷基（前提是当R.sup.1是基团--CO.sub.2R时，R.sup.2是较低的烷基）。该公式(I)的化合物可用作其他环系统的中间体，这些环系统具有药理学上的兴趣。其中某些公式(I)的化合物也可用作抗微生物剂。
• Pyrazolo (3,4-d) pyrimidines and methods of making
  申请人：Burroughs Wellcome Co.

  公开号：US04260758A1

  公开（公告）日：1981-04-07

  Novel compounds of the general formula (XIX) ##STR1## where R.sup.9 is selected from lower alkyl, phenyl, phenyl substituted by one or more hydroxy or lower alkoxy, or pyridyl, are disclosed. A method of making the compounds of Formula (XIX) is disclosed, which comprises heating in aqueous acid a compound of formula (XX) ##STR2## wherein R.sup.10 is selected from lower alkyl, phenyl, phenyl substituted by one or more hyroxy or lower alkoxy or pyridyl and R.sup.11 is selected from lower alkyl, phenyl, substituted by one or more hydroxy or lower alkoxy, pyridyl or --CO.sub.2 R where R is lower alkyl.

  本发明揭示了一般式（XIX）的新化合物：##STR1## 其中R.sup.9从低烷基、苯基、被一个或多个羟基或低烷氧基取代的苯基或吡啶基中选择。本发明还揭示了一种制备式（XIX）化合物的方法，其中包括在水酸中加热式（XX）化合物：##STR2## 其中R.sup.10从低烷基、苯基、被一个或多个羟基或低烷氧基取代的苯基或吡啶基中选择，R.sup.11从低烷基、苯基、被一个或多个羟基或低烷氧基取代的苯基、吡啶基或--CO.sub.2 R（其中R是低烷基）中选择。
• Method of using 1H-pyrimido-4,5-c -1,2-diazepines as antibacterial and
  申请人：Burroughs Wellcome Co.

  公开号：US04315932A1

  公开（公告）日：1982-02-16

  Compounds of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from a lower alkyl group, a phenyl group (optionally substituted by one or more hydroxy or lower alkoxy groups), a pyridyl group or a group --CO.sub.2 R where R is a lower alkyl group, (provided that when R.sup.1 is a group --CO.sub.2 R, R.sup.2 is a lower alkyl group) are disclosed. The compounds of formula (I) are useful as intermediates to compounds of other ring systems which are of pharmacological interest. Certain of the compounds of formula (I) are also useful as antimicrobial agents.

  通式（I）的化合物##STR1##其中R.sup.1和R.sup.2选自较低的烷基，苯基（可选地被一个或多个羟基或较低的烷氧基置换），吡啶基或羧基--CO.sub.2 R，其中R是较低的烷基（但当R.sup.1是羧基--CO.sub.2 R时，R.sup.2是较低的烷基）已被披露。公式（I）的化合物可用作其他药理学感兴趣的环系化合物的中间体。公式（I）的某些化合物也可用作抗微生物剂。
• Pyrido derivatives
  申请人：Burroughs Wellcome Co.

  公开号：US04288365A1

  公开（公告）日：1981-09-08

  Compounds of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from a lower alkyl group, a phenyl group (optionally substituted by one or more hydroxy or lower alkoxy groups), a pyridyl group or a group --CO.sub.2 R where R is a lower alkyl group, (provided that when R.sup.1 is a group --CO.sub.2 R, R.sup.2 is a lower alkyl group) are disclosed. The compounds of formula (I) are useful as intermediates to compounds of other ring systems which are of pharmacological interest. Certain of the compounds of formula (I) are also useful as antimicrobial agents.

  通式（I）的化合物如下：##STR1##其中R.sup.1和R.sup.2选自低碳基、苯基（可以选择性地被一个或多个羟基或低烷氧基取代）、吡啶基或羧基--CO.sub.2 R，其中R是低碳基（但当R.sup.1是羧基--CO.sub.2 R时，R.sup.2为低碳基）。该式（I）的化合物可用作其他具有药理学意义的环系统的中间体。其中某些式（I）的化合物还可用作抗微生物剂。