3-(4-fluorophenyl)furan-2-carboxylic acid | 1423027-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 3-(4-fluorophenyl)furan-2-carboxylic acid
• CAS: 1423027-10-4
• 化学式: C₁₁H₇FO₃
• mdl: MFCD22566089
• 分子量: 206.173
• InChiKey: AAKFSKGDIRKILO-UHFFFAOYSA-N

物化性质

• 沸点：
  321.7±32.0 °C(Predicted)
• 密度：
  1.336±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-methyl-N1-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)benzene-1,3-diamine 、 3-(4-fluorophenyl)furan-2-carboxylic acid 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以69.4 %的产率得到3-(4-fluorophenyl)-N-[4-methyl-3-[[3-(9-tetrahydropyran-2-ylpurin-6-yl)-2-pyridyl]amino]phenyl]furan-2-carboxamide
  参考文献：
  名称：

  [EN] MODULATORS OF PROTEIN KINASES
  [FR] MODULATEURS DE PROTÉINES KINASES

  摘要：

  Provided herein are small molecule protein kinase modulators having the formula I Pharmaceutical compositions comprising such, and their uses in treating one or more conditions are also disclosed.

  公开号：

  WO2023183444A1
• 作为产物：
  描述：

  Ethyl 3-(4-fluorophenyl)furan-2-carboxylate 在 sodium hydroxide 作用下， 以90.7 %的产率得到3-(4-fluorophenyl)furan-2-carboxylic acid
  参考文献：
  名称：

  [EN] MODULATORS OF PROTEIN KINASES
  [FR] MODULATEURS DE PROTÉINES KINASES

  摘要：

  Provided herein are small molecule protein kinase modulators having the formula I Pharmaceutical compositions comprising such, and their uses in treating one or more conditions are also disclosed.

  公开号：

  WO2023183444A1

文献信息

• Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose
  申请人：Alcon Laboratories, Inc.

  公开号：US05153211A1

  公开（公告）日：1992-10-06

  Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome. A particularly preferred class of compounds comprise difluoro-dialkoxy substituted spiro-(9H-fluorene-9,4'-imidazolidine)-2',5-diones.

  本发明涉及取代或未取代的平面三环芴或其核类似物，与含有次级酰胺的五元环螺合，以及其药学上可接受的盐。这些化合物在糖尿病的治疗中有用。本发明还涉及制备这些化合物的方法；包含这些化合物的制药组合物；以及在适用于糖尿病综合症的长期预防性治疗等情况下，通过给予这些化合物和组合物进行治疗的方法。一种特别优选的化合物类别包括二氟二烷氧基取代的螺-(9H-芴-9,4'-咪唑啉)-2',5-二酮。
• Spiro-tricyclicaromatic succinimide derivatives
  申请人：Alcon Laboratories, Inc.

  公开号：US04864028A1

  公开（公告）日：1989-09-05

  Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically acceptable salts thereof. These compounds are useful, inter alia, in the treatment of diabetes. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when indicated for, inter alia, long term, prophylactic treatment of the diabetes syndrome.

  本发明涉及取代或未取代的平面三环芴或其核类似物，与含有次级酰胺的五元环螺合成的化合物及其药学上可接受的盐。这些化合物在糖尿病治疗中有用，此外还揭示了制备这些化合物的方法；包括这些化合物的制药组合物；以及在适当时用于糖尿病综合症的长期预防性治疗的方法，其中包括给予这些化合物和组合物。
• Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
  申请人：ALCON LABORATORIES, INC.

  公开号：EP0137333B1

  公开（公告）日：1992-12-30
• BICYCLIC KINASE INHIBITORS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1025102A1

  公开（公告）日：2000-08-09
• US4537892A
  申请人：——

  公开号：US4537892A

  公开（公告）日：1985-08-27