Methyl 2-[(2-methylpropan-2-yl)oxycarbonyl-[(2-methylpropan-2-yl)oxycarbonylamino]amino]propanedithioate | 140869-62-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: Methyl 2-[(2-methylpropan-2-yl)oxycarbonyl-[(2-methylpropan-2-yl)oxycarbonylamino]amino]propanedithioate
• CAS: 140869-62-1
• 化学式: C₁₄H₂₆N₂O₄S₂
• 分子量: 350.503
• InChiKey: NTERNOYFZSMCIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  甘氨酸乙酯盐酸盐 、 Methyl 2-[(2-methylpropan-2-yl)oxycarbonyl-[(2-methylpropan-2-yl)oxycarbonylamino]amino]propanedithioate 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 30.0h， 以69%的产率得到1,2-Hydrazinedicarboxylic acid,1-[2-[(2-ethoxy-2-oxoethyl)amino]-1-methyl-2-thioxoethyl]-,bis(1,1-dimethylethyl) ester
  参考文献：
  名称：

  Mono S-trimethylsilyl ketene dithioacetals as versatile tools for the synthesis of α-hydrazinodithioesters. A novel access to endothiopeptides.

  摘要：

  Mono-S-trimethylsilylketene dithioacetals have been prepared from dithioesters by the action of trimethylsilyl iodide formed in situ. They were reacted easily with dialkylazodicarboxylates to give good yields of alpha-hydrazinodithioesters. The latter were transformed into thioamides or endothiodipeptides by aminolysis either with an amine or an amino acid.

  DOI：

  10.1016/s0040-4039(00)91580-6
• 作为产物：
  描述：

  偶氮二甲酸二叔丁酯 、 Trimethyl-((Z)-1-methylsulfanyl-propenylsulfanyl)-silane 在 溶剂黄146 作用下， 以72%的产率得到Methyl 2-[(2-methylpropan-2-yl)oxycarbonyl-[(2-methylpropan-2-yl)oxycarbonylamino]amino]propanedithioate
  参考文献：
  名称：

  Mono S-trimethylsilyl ketene dithioacetals as versatile tools for the synthesis of α-hydrazinodithioesters. A novel access to endothiopeptides.

  摘要：

  Mono-S-trimethylsilylketene dithioacetals have been prepared from dithioesters by the action of trimethylsilyl iodide formed in situ. They were reacted easily with dialkylazodicarboxylates to give good yields of alpha-hydrazinodithioesters. The latter were transformed into thioamides or endothiodipeptides by aminolysis either with an amine or an amino acid.

  DOI：

  10.1016/s0040-4039(00)91580-6