tetraaza-1,6,11,16 cycloeicosane | 3713-77-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tetraaza-1,6,11,16 cycloeicosane
• 英文别名: 1,6,11,16-tetrazacycloeicosane；1,6,11,16-Tetraazacycloeicosane；1,6,11,16-tetrazacycloicosane
• CAS: 3713-77-7
• 化学式: C₁₆H₃₆N₄
• 分子量: 284.489
• InChiKey: UMGSKBOLFKYPNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  48.1
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N¹,N⁵,N¹⁰,N¹⁴-tetra(p-toluenesulfonyl)-1,14-diamino-5,10-diazatetradecane 在 硫酸 、 sodium hydride 作用下， 生成 tetraaza-1,6,11,16 cycloeicosane
  参考文献：
  名称：

  四胺四环芳烃的络合物。

  摘要：

  简要描述了新的四氮杂大环[20] N 4的合成。研究了完全质子化的[16] N 4，[18] N 4和[20] N 4大环对F的络合作用。

  DOI：

  10.1016/s0040-4039(00)99960-x

文献信息

• Compositions and Methods for Cellular Imaging and Therapy
  申请人：Yang J. David

  公开号：US20070248537A1

  公开（公告）日：2007-10-25

  The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving N 4 compounds and derivatives.

  本发明一般涉及化学和放射性核素成像领域。更具体地，涉及涉及N4化合物及其衍生物的成分、试剂盒和成像和治疗方法。
• COMPOSITIONS AND METHODS FOR CELLULAR IMAGING AND THERAPY
  申请人：The Board of Regents of The University of Texas System

  公开号：EP2013221B1

  公开（公告）日：2015-06-24
• METHODS AND COMPOSITIONS USING CHELATOR-ANTIBODY CONJUGATES
  申请人：Kurzrock Razelle

  公开号：US20100104511A1

  公开（公告）日：2010-04-29

  Disclosed are pharmaceutical compositions that include a chelator and an antibody directed against a phosphorylation site of a protein, wherein the antibody is conjugated to the chelator to form a chelator-antibody conjugate. For example, the antibody may recognize a phosphorylated tyrosine residue or a phosphorylated serine residue of a cell surface receptor. Also disclosed are methods of synthesizing a radiolabeled chelator-antibody conjugate, wherein the antibody is directed against a phosphorylation site of a protein. Also disclosed are methods for imaging a site in a subject that involve administering to the subject an effective amount of a composition that includes a valent metal ion-labeled chelator-antibody conjugate, wherein the antibody is an antibody directed against a phosphorylation site of a protein, and detecting a radioactive signal from the site in the subject following administration of an effective amount of the composition. The method of imaging can be applied in diagnosing a tumor, such as a tumor that can be responsive to therapy using a tyrosine kinase inhibitor, and in the treatment of a tumor, such as by targeting therapy to cell surface receptors that include phosphorylation sites.
• US8758723B2
  申请人：——

  公开号：US8758723B2

  公开（公告）日：2014-06-24
• [EN] COMPOSITIONS AND METHODS FOR CELLULAR IMAGING AND THERAPY<br/>[FR] COMPOSITIONS ET MÉTHODES POUR IMAGERIE CELLULAIRE ET THÉRAPIE
  申请人：UNIV TEXAS

  公开号：WO2007120153A1

  公开（公告）日：2007-10-25

  [EN] The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits, and methods for imaging and therapy involving N4 compounds and derivatives.
  [FR] La présente invention concerne de manière générale les domaines de la chimie et de l'imagerie par radionucléides. Plus particulièrement, la présente invention concerne des compositions, des kits et des méthodes d'imagerie et de thérapie impliquant des composés N4 ainsi que leurs dérivés.