24-methylenecholest-5-ene-3β,16β-diol-3-O-α-L-fucopyranoside | 132214-23-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 24-methylenecholest-5-ene-3β,16β-diol-3-O-α-L-fucopyranoside
• 英文别名: (2R,3S,4R,5S,6S)-2-[[(3S,8S,9S,10R,13S,14S,16S,17R)-16-hydroxy-10,13-dimethyl-17-[(2R)-6-methyl-5-methylideneheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-methyloxane-3,4,5-triol
• CAS: 132214-23-4
• 化学式: C₃₄H₅₆O₆
• 分子量: 560.815
• InChiKey: AZOQCLUPGYXSJW-FJPRSBCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  40
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  24-methylenecholest-5-ene-3β,16β-diol-3-O-α-L-fucopyranoside 生成 (3S,8S,9S,10R,13S,14S,16S,17R)-17-[(E,2R)-5,6-dimethylhept-4-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,16-diol
  参考文献：
  名称：

  KOBAYASHI, MASARU;KANDA, FUYUKO;DAMARLA, SRINIVASA RAO;RAO, DESARAJU VENK+, CHEM. AND PHARM. BULL., 38,(1990) N, C. 2400-2403

  摘要：

  DOI：

文献信息

• Marine sterols. XVII. Polyhydroxysterols of the soft corals of the andaman and nicobar coasts. (2). Isolation and atructures of three 16.BETA.-hydroxy steroidal glycosides from an Alcyonium sp. soft coral.
  作者：Masaru KOBAYASHI、Fuyuko KANDA、Srinivasa Rao DAMARLA、Desaraju Venkata RAO、Chaganti Bheemasankara RAO

  DOI：10.1248/cpb.38.2400

  日期：——

  3β, 7β-Dihydroxy-24-methylenecholesterol (1) and three new polyhydroxysterol glycosides (2a, 3a and 4) were isolated from the lipid extract of an Alcyonium sp. soft coral which was collected in the Andaman and Nicobar Islands. Isolation of steroidal glycosides from soft corals is rare, if not unprecedented. Spectroscopic and chemical degradation studies indicated the new glycosides to be 24-methylenecholest-5-ene-3β, 16β-diol-3-O-α-L-fucoside (2a) and its 7β- (3a) and 7α-hydroxy (4) derivatives.

  从安达曼和尼科巴群岛采集的一种 Alcyonium sp.软珊瑚的脂质提取物中分离出了 3β、7β-二羟基-24-亚甲基胆固醇（1）和三种新的多羟基甾醇苷（2a、3a 和 4）。从软珊瑚中分离出甾体苷是罕见的，甚至是前所未有的。光谱和化学降解研究表明，新的苷类是 24-亚甲基胆甾烯-5-烯-3β，16β-二醇-3-O-α-L-岩藻糖苷（2a）及其 7β- （3a）和 7α- 羟基（4）衍生物。
• Subrahmanyam, Chitti; Rao, Chirravuri Venkateswara; Kobayashi, Masaru, Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, <hi>1993</hi>, vol. 32, # 12, p. 1298 - 1299
  作者：Subrahmanyam, Chitti、Rao, Chirravuri Venkateswara、Kobayashi, Masaru

  DOI：——

  日期：——