(7S,9S)-7-<(3'-amino-2',3',6'-trideoxy-α-L-lyxohexopyranosyl)oxy>-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-<<<(4-methoxyphenyl)carbamoyl>oxy>methyl>-5,12-naphthacenedione hydrochloride | 91684-90-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 英文名称: (7S,9S)-7-<(3'-amino-2',3',6'-trideoxy-α-L-lyxohexopyranosyl)oxy>-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-<<<(4-methoxyphenyl)carbamoyl>oxy>methyl>-5,12-naphthacenedione hydrochloride
• 英文别名: (1S)-cis-1-[(3-amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-3-(4-methoxyphenylcarbamoyloxy)methyl-6,11-dioxonaphthacene hydrochloride；[(2S,4S)-4-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]methyl N-(4-methoxyphenyl)carbamate;hydrochloride
• CAS: 91684-90-1
• 化学式: C₃₃H₃₄N₂O₁₁*ClH
• 分子量: 671.101
• InChiKey: OSHHLUDABDBHCU-LUPOYPIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.11
• 重原子数：
  47
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  207
• 氢给体数：
  7
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  (7S,9S)-7,8,9,10-tetrahydro-6,7,9,11-terahydroxy-9-<<<(4-methoxyphenyl)carbamoyl>oxy>methyl>-5,12-naphthacenedione 、 1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose 生成 (7S,9S)-7-<(3'-amino-2',3',6'-trideoxy-α-L-lyxohexopyranosyl)oxy>-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-<<<(4-methoxyphenyl)carbamoyl>oxy>methyl>-5,12-naphthacenedione hydrochloride
  参考文献：
  名称：

  ADAMS, NIGEL;BLAKE, COLIN;BROADHURST, MICHAEL J.;BUSHNELL, DAVID J.;HASSA+, J. MED. CHEM., 33,(1990) N, C. 2380-2384

  摘要：

  DOI：

文献信息

• US4526960A
  申请人：——

  公开号：US4526960A

  公开（公告）日：1985-07-02