2-chloro-6-methoxy-1,4-naphthoquinone | 76665-66-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-chloro-6-methoxy-1,4-naphthoquinone
• 英文别名: 2-Chloro-6-methoxynaphthalene-1,4-dione
• CAS: 76665-66-2
• 化学式: C₁₁H₇ClO₃
• 分子量: 222.628
• InChiKey: ODEFKYWFKBPTFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [(1E)-1-methoxy-3-methyl-2-trimethylsilyloxybuta-1,3-dienoxy]-trimethylsilane 、 2-chloro-6-methoxy-1,4-naphthoquinone 生成 (1R,4aS,9aR)-9a-Chloro-1,6-dimethoxy-3-methyl-1,2-bis-trimethylsilanyloxy-1,4,4a,9a-tetrahydro-anthraquinone
  参考文献：
  名称：

  Synthesis of specifically O-alkylated anthraquinones by cycloaddition

  摘要：

  DOI：

  10.1016/s0040-4039(00)85117-5
• 作为产物：
  描述：

  2-甲氧基-1,3-丁二烯 、 2,5-二氯-1,4-苯醌 、 二氯甲烷 、 sodium acetate 、 甲醇 以65%的产率得到
  参考文献：
  名称：

  CAMERON D. W.; FEUTRILL G. I.; GAMBLE G. B.; STAVRAKIS J., TETRAHEDRON LETT., 27,(1986) N 41, 4999-5002

  摘要：

  DOI：

文献信息

• Naphthalene anti-psoriatic agents
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0150831A2

  公开（公告）日：1985-08-07

  Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: wherein: R' is alkoxy of one to twelve carbon atoms, of one to twelve carbon atoms, alkylthio of one to twelve carbon atoms, optionally substituted phenoxy or optionally substituted phenylthio; R2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl; R3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2, or R3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O)nR wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and W is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl.

  哺乳动物的牛皮癣可通过局部施用式中的萘来缓解： 其中 R'是一至十二个碳原子的烷氧基、一至十二个碳原子的烷氧基、一至十二个碳原子的烷硫基、任选取代的苯氧基或任选取代的苯硫基； R2 是氢、低级烷基、任选取代的苯基或任选取代的苯基烷基； R3 是低级烷基、低级烷氧基或卤素，m 是 0、1 或 2，或者 R3 是任选取代的苯基、任选取代的苯基低级烷基、任选取代的苯基低级烷氧基、氨基、低级烷基氨基、低级二烷基氨基、氰基或 S(O)nR 其中 R 是低级烷基；任选取代的苯基；任选取代的苯基低级烷基；或任选取代的三至九个环原子的杂环芳基，含有一个或两个选自氮、氧和硫的杂原子，以及它们的药学上可接受的酸加成盐；且 m 为 1，n 为 0、1 或 2；以及 W 是一至七个碳原子的烷基、任选取代的苯基或任选取代的苄基。
• Naphtalene anti-psoriatic agents
  申请人：SYNTEX (U.S.A.) INC.

  公开号：EP0282006A1

  公开（公告）日：1988-09-14

  Psoriasis in mammals is relieved by administering naphthalenes of the formula: wherein:     R¹ is lower alkoxy or optionally substituted phenoxy;     R² is hydrogen, lower alkyl, lower alkoxy, optionally substituted phenyl, optionally substituted phenoxy or optionally substituted phenylalkyl;     R³ is hydrogen, lower alkyl, lower alkoxy, halo, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl or optionally substituted phenyl-lower-­alkoxy, and m is 1 or 2;     X and Y may be different or are the same, and if different are either R⁴ or -C(O)W, and if the same are both -C(O)W, wherein     R⁴ is lower alkyl or optionally substituted phenyl-lower-alkyl;     W is -OR⁵ or -NR⁶R⁷,     wherein R⁵ is alkyl, optionally substituted phenyl or optionally substituted benzyl; and R⁶ and R⁷ are independently hydrogen, lower alkyl, cycloalkyl or optionally substituted phenyl.

  哺乳动物的牛皮癣可通过服用式中的萘来缓解： 其中 R¹ 是低级烷氧基或任选取代的苯氧基； R² 是氢、低级烷基、低级烷氧基、任选取代的苯基、任选取代的苯氧基或任选取代的苯基烷基； R³ 是氢、低级烷基、低级烷氧基、卤代、任选取代的苯基、任选取代的苯基-低级烷基或任选取代的苯基-低级烷氧基，且 m 是 1 或 2； X 和 Y 可以不同或相同，如果不同，则为 R⁴ 或 -C(O)W，如果相同，则均为 -C(O)W、 其中 R⁴ 是低级烷基或任选取代的苯基-低级烷基； W 是-OR⁵或-NR⁶R⁷、 其中 R⁵ 是烷基、任选取代的苯基或任选取代的苄基；以及 R⁶ 和 R⁷ 独立地为氢、低级烷基、环烷基或任选取代的苯基。
• Abdallah, Abdallah Awad; Gesson, Jean-Pierre; Jacquesy, Jean-Claude, Bulletin de la Societe Chimique de France, 1986, # 1, p. 93 - 100
  作者：Abdallah, Abdallah Awad、Gesson, Jean-Pierre、Jacquesy, Jean-Claude、Mondon, Martine

  DOI：——

  日期：——
• CAMERON D. W.; FEUTRILL G. I.; GAMBLE G. B.; STAVRAKIS J., TETRAHEDRON LETT., 27,(1986) N 41, 4999-5002
  作者：CAMERON D. W.、 FEUTRILL G. I.、 GAMBLE G. B.、 STAVRAKIS J.

  DOI：——

  日期：——
• RADICAL POLYMERIZATION CONTROL AGENT AND RADICAL POLYMERIZATION CONTROL METHOD
  申请人：Kawasaki Kasei Chemicals Ltd.

  公开号：US20210122692A1

  公开（公告）日：2021-04-29

  A conventional polymerization inhibitor is for example an agent to scavenge radicals generated during storage of a radical polymerizable compound and used to stably handle the radical polymerizable compound, but is unnecessary when the radical polymerizable compound is to be subjected to radical polymerization reaction, and is preferably removed at the time of the radical polymerization reaction. The object of the present invention is to obviate inconvenience of removing the polymerization inhibitor at the time of radical polymerization. The radical polymerization control agent contained in a radical polymerizable composition of the present invention functions as a radical polymerization inhibitor for example stored in a dark place, but loses its radical polymerization inhibiting effect when polymerization is initiated while being irradiated with light at a certain specific wavelength at the time of polymerization. Thus, radical polymerization of the radical polymerizable compound is easily initiated without increasing the amount of a radical polymerization initiator. That is, the radical polymerization control agent of the present invention is a radical polymerization control agent which is a corn pound having an effect to inhibit radical polymerization of a radical polymerizable compound and which loses the radical polymerization inhibiting effect under irradiation with light rays containing light within a wavelength range of from 300 nm to 500 nm.