2-ethyl-3-(morpholinomethyl)quinazolin-4(3H)-one | 67130-16-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-ethyl-3-(morpholinomethyl)quinazolin-4(3H)-one
• 英文别名: 2-ethyl-3-(morpholin-4-ylmethyl)quinazolin-4-one
• CAS: 67130-16-9
• 化学式: C₁₅H₁₉N₃O₂
• 分子量: 273.335
• InChiKey: JAMIEEUPUCBZMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  45.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  C₁₅H₂₁N₃O₃ 以 formamide 为溶剂， 反应 0.17h， 生成 2-ethyl-3-(morpholinomethyl)quinazolin-4(3H)-one
  参考文献：
  名称：

  Rapid synthesis of 2,3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide

  摘要：

  An efficient methodology for the preparation of a series of 2,3-disubstituted-quinazolin-4(3H) -ones is described via a three step reaction from anthranilic acid. The obtained results also reveal that microwave-assisted rapid decomposition of formamide under controlled conditions of power, temperature and time is a very convenient source of ammonia for the synthesis of 2-substituted-quinazolin-4(3H)-ones and other rings. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.114

文献信息

• SELIM M.; SAMMOUR A.; ABDALLA M.; ELKASABY M., PAKISTAN J. SCI. RES. <PSIR-AA>, 1975, 27, NO 1-4, 67-72
  作者：SELIM M.、 SAMMOUR A.、 ABDALLA M.、 ELKASABY M.

  DOI：——

  日期：——
• Rapid synthesis of 2,3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide
  作者：Ioannis K. Kostakis、Abdelhakim Elomri、Elisabeth Seguin、Mauro Iannelli、Thierry Besson

  DOI：10.1016/j.tetlet.2007.07.114

  日期：2007.9

  An efficient methodology for the preparation of a series of 2,3-disubstituted-quinazolin-4(3H) -ones is described via a three step reaction from anthranilic acid. The obtained results also reveal that microwave-assisted rapid decomposition of formamide under controlled conditions of power, temperature and time is a very convenient source of ammonia for the synthesis of 2-substituted-quinazolin-4(3H)-ones and other rings. (c) 2007 Elsevier Ltd. All rights reserved.