6,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-carboxylic acid chloride | 76903-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-carboxylic acid chloride
• 英文别名: 6,7-dihydroxychromone-3-carbonylchloride；6,7-dihydroxy-4-oxo-4H-1-benzopyran-3-carbonyl chloride；6,7-dihydroxychromon-3-carbonylchloride；6,7-dihydroxy-4-oxochromene-3-carbonyl chloride
• CAS: 76903-12-3
• 化学式: C₁₀H₅ClO₅
• 分子量: 240.6
• InChiKey: XHDRIAFCYSITRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-carboxylic acid chloride 、 benzhydryl (6R,7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(2-hydrazinyl-2-oxoethoxy)imino-2-[2-(tritylamino)-1,3-thiazol-4-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 生成
  参考文献：
  名称：

  WEINGARTEN, GORDON GAD

  摘要：

  DOI：
• 作为产物：
  描述：

  6,7-Dihydroxychromon-3-carbonsaeure 以 氯化亚砜 、 甲苯 为溶剂， 生成 6,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-carboxylic acid chloride
  参考文献：
  名称：

  2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines

  摘要：

  3-酰氨基-2-氧代杂环丁烷具有抗菌活性，在1-位置带有如下式中的活化基团##STR1##其中R为##STR2##，R.sub.4为##STR3##

  公开号：

  US04777252A1

文献信息

• 7-Carboxymethoxyphenylacetamido-3-cephem derivatives and antibacterial
  申请人：Eisai Co., Ltd.

  公开号：US04546176A1

  公开（公告）日：1985-10-08

  7-Carboxymethoxyphenylacetamido-3-cephem derivatives represented by the formula ##STR1## wherein R.sub.1 means hydroxy, C.sub.1 -C.sub.4 alkanoyloxy or C.sub.1 -C.sub.4 alkoxycarbonyloxy, R.sub.2 is hydrogen or methoxy, R.sub.3 denotes C.sub.1 -C.sub.4 alkanoyloxy, substituted or unsubstituted nitrogen-containing heterocyclic-thio or substituted or unsubstituted pyridinium with a proviso that, when R.sub.3 denotes the substituted or unsubstituted pyridinium, R.sub.3 forms an intramolecular salt with the carboxy at the 4-position of the cephem nucleus, and A is a group of the following formula: ##STR2## in which R.sub.4 and R.sub.5 are individually hydrogen or C.sub.1 -C.sub.4 alkyl, and their pharmaceutically acceptable salts, exhibit excellent anti-bacterial activities against Gram-negative bacteria, particularly, Pseud. aeruginosa, Kleb. pneumoniae, Ser. marcescens and the like.

  7-羧甲氧基苯乙酰胺基-3-头孢菌素衍生物的化学式为##STR1##其中R.sub.1代表羟基，C.sub.1 -C.sub.4烷酰氧基或C.sub.1 -C.sub.4烷氧羰基氧基，R.sub.2为氢或甲氧基，R.sub.3表示C.sub.1 -C.sub.4烷酰氧基，取代或未取代的含氮杂环硫或取代或未取代的吡啶阳离子，但当R.sub.3表示取代或未取代的吡啶阳离子时，R.sub.3与头孢菌素核的4位羧基形成分子内盐，A为以下化学式的基团：##STR2##其中R.sub.4和R.sub.5分别为氢或C.sub.1 -C.sub.4烷基，及其药用可接受的盐，对革兰氏阴性细菌，特别是铜绿假单胞菌、克雷伯菌、马克赛菌等表现出优异的抗菌活性。
• 7.alpha.-Methoxycephalosporin derivatives, and antibacterial drugs
  申请人：Eisai Co., Ltd.

  公开号：US04415567A1

  公开（公告）日：1983-11-15

  Novel 7.alpha.-methoxycephalosporin derivatives, their pharmaceutically acceptable salts, process for the preparation thereof, and antibacterial drugs involving the derivative or salt. The derivatives or salts are effective against the Gram-positive bacteria and the Gram-negative bacteria.

  小说7.alpha.-甲氧基头孢菌素衍生物，其药用盐，其制备方法，以及涉及该衍生物或盐的抗菌药物。这些衍生物或盐对革兰氏阳性菌和革兰氏阴性菌有效。
• Cephalosporin derivatives, and antibacterial drugs comprising said
  申请人：Eisai Co., Ltd.

  公开号：US04285940A1

  公开（公告）日：1981-08-25

  New cephalosporin derivatives having the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represents hydroxy or acyloxy and their salts, and processes for the production thereof. The cephalosporin derivatives of the present invention are useful as antibacterial drugs.

  新的头孢菌素衍生物具有一般式：##STR1## 其中R.sub.1和R.sub.2分别表示羟基或乙酰氧基及其盐，并且制备它们的工艺。本发明的头孢菌素衍生物可用作抗菌药物。
• Cephalosporin derivatives, and antibacterial drugs containing the
  申请人：Eisai Co., Ltd.

  公开号：US04285939A1

  公开（公告）日：1981-08-25

  New cephalosporin derivatives represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 each represents hydroxy, acyloxy, and hydrogen provided that two or three of R.sub.1, R.sub.2, and R.sub.3 are not hydrogen at the same time, and their salts, and processes for the preparation thereof. The cephalosporin derivatives of the present invention are useful as antibacterial drugs.

  新的头孢菌素衍生物，其通式为：##STR1## 其中R.sub.1，R.sub.2和R.sub.3分别表示羟基，酰氧基和氢，前提是R.sub.1，R.sub.2和R.sub.3中的两个或三个不同时为氢，以及它们的盐，以及制备它们的过程。本发明的头孢菌素衍生物可用作抗菌药物。
• Cephalosporin compounds and antibacterial drugs containing the same
  申请人：Eisai Co., Ltd.

  公开号：US04285941A1

  公开（公告）日：1981-08-25

  Novel cephalosporin compounds of the general formula: ##STR1## wherein R.sub.1 represents a substituted or unsubstituted nitrogen-containing heterocyclic-thio group, R.sub.2 represents hydrogen or hydroxy, and R.sub.3, R.sub.4 and R.sub.5 each represents hydrogen, hydroxy or acyloxy, and their salts, and processes for the preparation thereof. The novel compounds and their salts have antibacterial activity.

  一种新型头孢菌素化合物，其一般式为：##STR1## 其中R.sub.1代表取代或未取代的含氮杂环硫基，R.sub.2代表氢或羟基，R.sub.3、R.sub.4和R.sub.5分别代表氢、羟基或酰氧基，以及它们的盐，并提供制备它们的方法。这种新型化合物及其盐具有抗菌活性。