4-Propionamido-methylphenol | 34190-41-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-Propionamido-methylphenol
• 英文别名: N-[(4-hydroxyphenyl)methyl]propanamide
• CAS: 34190-41-5
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: NFIZSZNOXHNKEN-UHFFFAOYSA-N

物化性质

• 熔点：
  94-96 °C
• 沸点：
  420.8±28.0 °C(Predicted)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Propionamido-methylphenol 以31%的产率得到
  参考文献：
  名称：

  SMITH L. H., J. MED. CHEM. , 1977, 20, NO 10, 1254-1258

  摘要：

  DOI：

文献信息

• [EN] DIRECTED CONJUGATION TECHNOLOGIES<br/>[FR] TECHNOLOGIES DE CONJUGAISON DIRIGÉE
  申请人：KLEO PHARMACEUTICALS INC

  公开号：WO2021102052A1

  公开（公告）日：2021-05-27

  Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates.

  本公开提供了用于将各种感兴趣的分子与目标剂进行定点偶联的技术。在某些实施方式中，本公开利用目标结合分子以提供高偶联效率和选择性。在某些实施方式中，所提供的技术可用于制备抗体偶联物。
• [EN] BIARYL AMIDE OR UREA DERIVATIVES AS TRPV1 LIGANDS<br/>[FR] DÉRIVÉS DE BIARYL AMIDE OU D'URÉE EN TANT QUE LIGANDS DE TRPV1
  申请人：UNIV SIENA

  公开号：WO2015162216A1

  公开（公告）日：2015-10-29

  The present invention relates to high affinity compounds, able to bind the transient receptor potential cation channel, subfamily Vanilloid, type 1 or TRPV1. Being this receptor involved in pain processing and neurogenic inflammatory responses and being up-regulated during chronic pain conditions, the compounds of the invention find particular application in all medical conditions involving said receptors, in particular as agents for pain therapy and/or anti-inflammatory and/or cluster headache therapy and/or anti-oxidant and/or anti-cancer therapy. Moreover, the chemical structure of these compounds provides the opportunity of developing new radiotracers for Positron Emission Tomography (PET) imaging. These radiotracers are of great relevance for mapping TRPV1 receptors in (patho)physiological conditions.

  本发明涉及高亲和力化合物，能够结合瞬时受体电位阳离子通道，亚家族Vanilloid，类型1或TRPV1。由于这种受体参与疼痛处理和神经源性炎症反应，并且在慢性疼痛情况下上调，本发明的化合物在涉及该受体的所有医学状况中找到特定应用，特别是作为疼痛治疗和/或抗炎疗法和/或群集性头痛治疗和/或抗氧化剂和/或抗癌疗法的药物。此外，这些化合物的化学结构为开发新的正电子发射断层扫描（PET）成像的放射示踪剂提供了机会。这些放射示踪剂对于在（病理）生理条件下映射TRPV1受体具有重要意义。
• [EN] ANTIBODY DRUG CONJUGATES USING MATES TECHNOLOGY FOR DELIVERING CYTOTOXIC AGENTS<br/>[FR] CONJUGUÉS ANTICORPS-MÉDICAMENT UTILISANT UNE TECHNOLOGIE DE COUPLAGE POUR ADMINISTRER DES AGENTS CYTOTOXIQUES
  申请人：BIOHAVEN THERAPEUTICS LTD

  公开号：WO2022246086A1

  公开（公告）日：2022-11-24

  Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates.

  除其他事项外，本公开提供了用于将各种感兴趣的物质定向结合到目标试剂上的技术。在某些实施例中，本公开利用目标结合物质提供高结合效率和选择性。在某些实施例中，提供的技术对于制备抗体结合物很有用。
• COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE
  申请人：Shy Therapeutics LLC

  公开号：EP3394056B1

  公开（公告）日：2021-04-14
• [EN] TETRAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS DE TÉTRAZOLE
  申请人：MERCK SERONO SA

  公开号：WO2011006935A2

  公开（公告）日：2011-01-20

  The present invention relates to compounds of formula (I) for use as pharmaceutical active compounds, as well as pharmaceutical formulations containing the same, for the treatment of allergic diseases.