2H-1,4-Benzoxazine, 4-(3-bromopropyl)-3,4-dihydro- | 515861-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 2H-1,4-Benzoxazine, 4-(3-bromopropyl)-3,4-dihydro-
• 英文别名: 4-(3-bromopropyl)-2,3-dihydro-1,4-benzoxazine
• CAS: 515861-33-3
• 化学式: C₁₁H₁₄BrNO
• 分子量: 256.14
• InChiKey: JMPGNDCSFIQLFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,4-二氢-2H-1,4-苯并噁嗪 、 1,3-二溴丙烷 、 disodium;carbonate 在 水 、 Brine 作用下， 以 N,N-二甲基甲酰胺 、 乙酸乙酯 为溶剂， 反应 16.0h， 以to yield 3-(3,4-Dihydro-2H-benzo[b][1,4]oxazin-4-yl)propyl bromide as liquid mass (2.6 g, 47%)的产率得到2H-1,4-Benzoxazine, 4-(3-bromopropyl)-3,4-dihydro-
  参考文献：
  名称：

  Novel beta-phenyl-alpha-oxysubstituted propionic derivatives: process for its preparation and their use in the preparation of pharmaceutically important compounds

  摘要：

  本发明涉及新型丙酸衍生物。更具体地，本发明涉及一般式（I）的β-苯基α-氧代取代丙酸。本发明还涉及制备式（I）化合物的方法及其在制备式（II）化合物中的应用。

  公开号：

  US20110105748A1

文献信息

• Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them
  申请人：Bhuniya Debnath

  公开号：US20050113368A1

  公开（公告）日：2005-05-26

  The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I) their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. The present invention also relates to processes for the preparation of the compounds of formula (I), novel intermediates, processes for their preparation, their use in the preparation of the above said compounds and their use as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds.

  本发明涉及公式（I）的新型抗糖尿病、降脂、抗肥胖和降胆固醇化合物及其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和包含它们的药学上可接受的组合物，以及制备这些化合物的方法。更具体地说，本发明涉及一般的烷基羧酸及其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和包含它们的药学上可接受的组合物，以及制备这些化合物的方法。本发明还涉及公式（I）化合物的制备方法、新型中间体的制备方法、以及它们在制备上述化合物和作为抗糖尿病、降脂、抗肥胖和降胆固醇化合物的用途。
• BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP1436268A1

  公开（公告）日：2004-07-14
• NOVEL-BETA-PHENYL-ALPHA-OXYSUBSTITUTED PROPIONIC DERIVATIVES: PROCESS FOR ITS PREPARATION AND THEIR USE IN THE PREPARATION OF PHARMACEUTICALLY IMPORTANT COMPOUNDS
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP1436247A1

  公开（公告）日：2004-07-14
• US7365064B2
  申请人：——

  公开号：US7365064B2

  公开（公告）日：2008-04-29
• [EN] NOVEL beta -PHENYL- alpha -OXYSUBSTITUTED PROPIONIC DERIVATIVES: PROCESS FOR ITS PREPARATION AND THEIR USE IN THE PREPARATION OF PHARMACEUTICALLY IMPORTANT COMPOUNDS<br/>[FR] DERIVES D'ACIDE PROPIONIQUE BETA-PHENYL-ALPHA-OXYSUBSTITUES, PROCEDES D'ELABORATION, ET UTILISATION DANS LA PREPARATION DE COMPOSES PHARMACEUTIQUES IMPORTANTS
  申请人：REDDYS LAB LTD DR

  公开号：WO2003033456A1

  公开（公告）日：2003-04-24

  The present invention relates to novel propionic acid derivatives. More particularly, the present invention relates to beta-phenyl alpha-oxysubstituted propionic acids of the general formula (I). The present invention also relates to processes for the preparation of compounds of the formula (I) and their use in the preparation of compounds of formula (II).