N-[7-hydroxy-5-(trifluoromethyl)-1,8-naphthyridin-2-yl]acetamide | 210642-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[7-hydroxy-5-(trifluoromethyl)-1,8-naphthyridin-2-yl]acetamide
• 英文别名: N-[7-oxo-5-(trifluoromethyl)-8H-1,8-naphthyridin-2-yl]acetamide
• CAS: 210642-92-5
• 化学式: C₁₁H₈F₃N₃O₂
• 分子量: 271.199
• InChiKey: UVLBDTKDWBHSQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[7-hydroxy-5-(trifluoromethyl)-1,8-naphthyridin-2-yl]acetamide 在 硫酸 、 三氯氧磷 作用下， 以 叔丁醇 为溶剂， 反应 123.5h， 生成 8-(3-ethylsulfonylimidazo[1,2-a]pyridin-2-yl)-4-(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridine
  参考文献：
  名称：

  [EN] TRICYCLIC PESTICIDAL COMPOUNDS
  [FR] COMPOSÉS PESTICIDES TRICYCLIQUES

  摘要：

  该发明涉及公式（I）的化合物，其中变量如规范中定义。它还涉及将公式（I）的化合物用作农药杀虫剂；包含公式（I）化合物的杀虫混合物；以及包含公式（I）化合物的农药或兽药组合物。其他目标是包含公式（I）化合物的种子；以及通过应用公式（I）化合物来控制无脊椎动物害虫、侵害或感染的方法。

  公开号：

  WO2021209265A1
• 作为产物：
  描述：

  2,6-二氨基吡啶 在 硫酸 作用下， 反应 14.0h， 生成 N-[7-hydroxy-5-(trifluoromethyl)-1,8-naphthyridin-2-yl]acetamide
  参考文献：
  名称：

  Synthesis of 1,8-naphthyridine derivatives: Potential antihypertensive agents — Part VII

  摘要：

  A series of 2-(carbethoxypiperazinyl)- and 2-piperazinyl-1,8-naphthyridine derivatives, variously substituted, have been synthesized and pharmacologically investigated for their antihypertensive activity. Some of them exhibited a significant and prolonged decrease of the mean arterial pressure (MAP) on spontaneously hypertensive rats. For this series of compounds, on the basis of the pharmacological results obtained, no structure-activity relationship can be deduced at this time. Moreover, the most active and representative compounds 11b, 12a and 16b were investigated by means of in vitro pharmacological functional studies and in vivo, as diuretic agents, to determine a possible mechanism of the antihypertensive activity, which is unknown for the moment. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80014-7

文献信息

• [EN] TRICYCLIC PESTICIDAL COMPOUNDS<br/>[FR] COMPOSÉS PESTICIDES TRICYCLIQUES
  申请人：BASF SE

  公开号：WO2021209265A1

  公开（公告）日：2021-10-21

  The invention relates to compounds of formula (I), wherein the variables are as defined in the specification. It also relates to the use of compounds of formula (I) as an agrochemical pesticide; to pesticidal mixtures comprising compounds of formula (I); and to agrochemical or veterinary compositions comprising compounds of formula (I). Other objects are seed comprising compounds of formula (I); and methods for controlling invertebrate pests, infestation, or infection by invertebrate pests by application of compounds of formula (I).

  该发明涉及公式（I）的化合物，其中变量如规范中定义。它还涉及将公式（I）的化合物用作农药杀虫剂；包含公式（I）化合物的杀虫混合物；以及包含公式（I）化合物的农药或兽药组合物。其他目标是包含公式（I）化合物的种子；以及通过应用公式（I）化合物来控制无脊椎动物害虫、侵害或感染的方法。
• Synthesis of 1,8-naphthyridine derivatives: Potential antihypertensive agents — Part VII
  作者：Pier Luigi Ferrarini、Claudio Mori、Muwaffag Badawneh、Vincenzo Calderone、Lorella Calzolari、Tiziana Loffredo、Enrica Martinotti、Giuseppe Saccomanni

  DOI：10.1016/s0223-5234(98)80014-7

  日期：1998.6

  A series of 2-(carbethoxypiperazinyl)- and 2-piperazinyl-1,8-naphthyridine derivatives, variously substituted, have been synthesized and pharmacologically investigated for their antihypertensive activity. Some of them exhibited a significant and prolonged decrease of the mean arterial pressure (MAP) on spontaneously hypertensive rats. For this series of compounds, on the basis of the pharmacological results obtained, no structure-activity relationship can be deduced at this time. Moreover, the most active and representative compounds 11b, 12a and 16b were investigated by means of in vitro pharmacological functional studies and in vivo, as diuretic agents, to determine a possible mechanism of the antihypertensive activity, which is unknown for the moment. (C) Elsevier, Paris.