5-methylallopurinol | 17840-75-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 5-methylallopurinol
• 英文别名: 4-Oxo-percent-methylpyrazolo<3,4-d>pyrimidin；5-methyl-1(2),5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one；5-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one；5-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-one
• CAS: 17840-75-4
• 化学式: C₆H₆N₄O
• 分子量: 150.14
• InChiKey: QMRATMRYQOVGBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-methylallopurinol 以80%的产率得到
  参考文献：
  名称：

  LEONOVA T. S.; BABUSHKINA T. A.; YASHUNSKIJ V. G., XIMIYA GETEROTSIKL. SOEDIN., 1978, HO 3, 397-402,

  摘要：

  DOI：

文献信息

• SULFONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE
  申请人：Emelen Van Kristof

  公开号：US20070142393A1

  公开（公告）日：2007-06-21

  This invention comprises the novel compounds of formula (I) wherein n, m, t, R 1 , R 2 , R 3 , R 4 , L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

  这项发明涉及公式（I）中的新化合物，其中n，m，t，R1，R2，R3，R4，L，Q，X，Y，Z和具有定义的含义，具有组织脱乙酰化酶抑制酶活性；它们的制备，包含它们的组合物以及它们作为药物的用途。
• Sulfonyl-Derivatives as Novel Inhibitors or Histone Deacetylase
  申请人：Van Emelen Kristof

  公开号：US20080108601A1

  公开（公告）日：2008-05-08

  This invention comprises the novel compounds of formula (I) wherein n, m, t, R 1 , R 2 , R 3 , R 4 , L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

  这项发明包括具有组成式（I）的新化合物，其中n，m，t，R1，R2，R3，R4，L，Q，X，Y，Z和具有定义的含义，具有组蛋白去乙酰化酶抑制酶活性；它们的制备，含有它们的组合物以及它们作为药物的用途。
• Inhibitors of Histone Deacetylase
  申请人：Moradei Oscar

  公开号：US20080132459A1

  公开（公告）日：2008-06-05

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制组蛋白去乙酰化酶的方法。本发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。本发明还提供了用于治疗细胞增殖性疾病和病状的组合物和方法。
• AMINOCARBONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE
  申请人：Van Emelen Kristof

  公开号：US20100048588A1

  公开（公告）日：2010-02-25

  This invention comprises the novel compounds of formula (I) wherein n, R 1 , R 2 , R 3 , R 4 , L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

  该发明涉及一种新颖的化合物，其化学式为(I)，其中n，R1，R2，R3，R4，L，Q，X，Y，Z和具有定义的含义，具有组蛋白去乙酰化酶抑制酶活性；它们的制备，含有它们的组合物以及它们作为药物的用途。
• Sulfonyl-Derivatives as Novel or Histone Deacetylase
  申请人：Van Emelen Kristof

  公开号：US20100240639A1

  公开（公告）日：2010-09-23

  This invention comprises the novel compounds of formula (I) wherein n, m, t, R 1 , R 2 , R 3 , R 4 , L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

  这项发明涉及公式(I)的新型化合物，其中n、m、t、R1、R2、R3、R4、L、Q、X、Y、Z和具有定义的含义，具有组蛋白去乙酰化酶抑制酶活性；它们的制备，含有它们的组合物以及它们作为药物的用途。