7-geranyloxy-1,3-dihydroxyxanthone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7-geranyloxy-1,3-dihydroxyxanthone
• 英文别名: 7-(3,7-Dimethylocta-2,6-dienoxy)-1,3-dihydroxyxanthen-9-one；7-(3,7-dimethylocta-2,6-dienoxy)-1,3-dihydroxyxanthen-9-one
• 化学式: C₂₃H₂₄O₅
• 分子量: 380.441
• InChiKey: WOPKDKPJTJHLPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-geranyloxy-1,3-dihydroxyxanthone 、 4-溴苯磺酰氯 在 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 以75.2 mg的产率得到[1-(4-bromophenyl)sulfonyloxy-7-[(2E)-3,7-dimethylocta-2,6-dienoxy]-9-oxoxanthen-3-yl] 4-bromobenzenesulfonate
  参考文献：
  名称：

  Anti-Pseudomonas aeruginosa xanthones from the resin and green fruits of Cratoxylum cochinchinense

  摘要：

  Cochinchinones 1-L (1-3 and 13) along with 11 known xanthones (4-12,14, and 15) were isolated from the resin and green fruits of Cratoxylum cochinchinense. In addition, four new acetylated compounds (1619) were derivatized from 7-geranyloxy-1,3-dihydroxyxanthone (14) and 3-geranyloxy-1,7-dihydroxyxanthone (15). All compounds were characterized on the basis of spectroscopic analyses. The structures of cochinchinone I (1), a monoacetate (18) and a dibrosylate (20), were also confirmed by X-ray diffraction analysis. The antibacterial and antifungal activities of selected Compounds were evaluated as well. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.01.083