N-pyridin-4-yl-1,4-diazepane-1-carboxamide | 1036740-21-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂卓
• 英文名称: N-pyridin-4-yl-1,4-diazepane-1-carboxamide
• CAS: 1036740-21-2
• 化学式: C₁₁H₁₆N₄O
• 分子量: 220.274
• InChiKey: FLLOWPSCVMDISN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  57.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-benzyl-N-pyridin-4-yl-1,4-diazepane-1-carboxamide 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 N-pyridin-4-yl-1,4-diazepane-1-carboxamide
  参考文献：
  名称：

  WO2008/79945

  摘要：

  公开号：

文献信息

• ROCK INHIBITORS AND USES THEREOF
  申请人：Sebti Said M.

  公开号：US20090318684A1

  公开（公告）日：2009-12-24

  The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that inhibit Rho-protein associated kinase function. Compounds of the invention include piperazinyl pyridines, piperazinylmethyl pyridines, piperazinyl ureas and carbamates, piperazinyl pyridines and quinoilines (including isoquinliones) as well as piperazinyl (including piperazinylmethyl) pyridines and quinolines (including isoquinolines). Compounds of the invention disrupt Rho-kinase activation and function and significantly inhibit tumor cell growth and induce tumor cell death.
• US8993760B2
  申请人：——

  公开号：US8993760B2

  公开（公告）日：2015-03-31
• [EN] ROCK INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DES ROCKS ET LEURS UTILISATIONS
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2008079945A2

  公开（公告）日：2008-07-03

  [EN] The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that inhibit Rho - protein associated kinase function. Compounds of the invention include piperazinyl pyridines, piperazinylmethyl pyridines, piperazinyl ureas and carbamates, piperazinyl pyridines and quinoilines (including isoquinliones) as well as piperazinyl (including piperazinylmethyl) pyridines and quinolines (including isoquinolines). Compounds of the invention disrupt Rho-kinase activation and function and significantly inhibit tumor cell growth and induce tumor cell death.
  [FR] La présente invention concerne des compositions et procédés pour bloquer la croissance ou la prolifération de cellules cancéreuses et/ou induire la mort des cellules cancéreuses. Les compositions de la présente invention sont des composés qui inhibent la fonction kinase associée aux protéines Rho. Les composés de l'invention sont essentiellement les pipérazinyl pyridines, les pipérazinylméthyl pyridines, les pupérazinyl urées et carbamates, les pipérazinyl pyridines et quinoilines (y-compris les isoquinliones) ainsi que les pipérazinyl (y-compris pipérazinylméthyl) pyridines et quinolines (y-compris isoquinolines). Les composés de l'invention interrompent l'activation et la fonction des Rho-kinases et inhibent de façon notoire la croissance des cellules tumorales et induisent la mort des cellules tumorales.
• WO2008/79945
  申请人：——

  公开号：——

  公开（公告）日：——