6-bromo-2-(5-methyl-2-thienyl)benzoxazole | 537025-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 6-bromo-2-(5-methyl-2-thienyl)benzoxazole
• 英文别名: 6-bromo-2-(5-methyl-thiophen-2-yl)benzoxazole；6-Bromo-2-(5-methyl-thiophen-2-yl)-benzoxazole；6-bromo-2-(5-methylthiophen-2-yl)-1,3-benzoxazole
• CAS: 537025-51-7
• 化学式: C₁₂H₈BrNOS
• 分子量: 294.172
• InChiKey: WXXUBKWFKKICNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  54.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  、 5-甲基-2-噻吩甲酸 、 2-氨基-5-溴苯酚 生成 6-bromo-2-(5-methyl-2-thienyl)benzoxazole
  参考文献：
  名称：

  Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists

  摘要：

  本发明涉及一般式I的吡啶并咪唑酮衍生物，其中A、G和R1基团如申请中所定义，其互变异构体、立体异构体、混合物和盐具有有价值的药理特性，特别是与GPR119受体结合并调节其活性。

  公开号：

  US08772323B2

文献信息

• Bicyclic derivative, its production and use
  申请人：Oda Tsuneo

  公开号：US20050101647A1

  公开（公告）日：2005-05-12

  The present invention provides a heterocyclic compound having potent tyrosine kinase-inhibiting activity represented by formula: (wherein, R 1b is a C 6-10 aryl group which has substituent(s), and the like; T a is a single bond, a C 1-6 alkyl group, —CH 2 O—, and the like; X and Y are the same or different, and each is a nitrogen atom which may have substituent(s), and the like; the broken line is a single bond or a double bond; Z a is a nitrogen atom or CH; W is a single bond, an oxygen atom, and the like; Q is a C 6-10 aryl group which may have substituent(s) or an aromatic heterocyclic group which may have substituent(s)); or a salt thereof and a pharmaceutical composition comprising thereof.

  本发明提供了一种具有强效酪氨酸激酶抑制活性的杂环化合物，其化学式表示为：（其中，R1是具有取代基的C6-10芳基基团等；Ta是单键，C1-6烷基基团，—CH2O—等；X和Y相同或不同，每个都是氮原子，可以具有取代基等；断裂线是单键或双键；Z是氮原子或CH；W是单键，氧原子等；Q是具有取代基的C6-10芳基基团或具有取代基的芳香杂环基团）或其盐以及含有该化合物的药物组合物。
• PYRIDAZINONES AS GPR119 AGONISTS
  申请人：Grauert Matthias

  公开号：US20130172323A1

  公开（公告）日：2013-07-04

  The present invention relates to pyridazinone derivatives of general formula I, wherein the groups A, G and R 1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

  本发明涉及一般式I的吡啶并咪唑酮衍生物，其中A、G和R1基团如本申请中所定义，其互变异构体、立体异构体、其混合物和其盐，具有有价值的药理特性，特别是能够结合GPR119受体并调节其活性。
• BICYCLIC DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1460067A1

  公开（公告）日：2004-09-22

  The present invention provides a heterocyclic compound having potent tyrosine kinase-inhibiting activity represented by formula: (wherein, R1b is a C6-10 aryl group which has substituent(s), and the like; Ta is a single bond, a C1-6 alkyl group, -CH2O-, and the like; X and Y are the same or different, and each is a nitrogen atom which may have substituent(s), and the like; the broken line is a single bond or a double bond; Za is a nitrogen atom or CH; W is a single bond, an oxygen atom, and the like; Q is a C6-10 aryl group which may have substituent(s) or an aromatic heterocyclic group which may have substituent(s)); or a salt thereof and a pharmaceutical composition comprising thereof.

  本发明提供了一种具有强效酪氨酸激酶抑制活性的杂环化合物，由式表示： (其中，R1b是具有取代基等的C6-10芳基；Ta是单键、C1-6烷基、-CH2O-等；X和Y相同或不同，且各自是可具有取代基等的氮原子；断线是单键或双键；Za是氮原子或CH；W是单键、氧原子等；Q是可能具有取代基的C6-10芳基或可能具有取代基的芳香杂环基团；或其盐和包含其的药物组合物。
• US7622479B2
  申请人：——

  公开号：US7622479B2

  公开（公告）日：2009-11-24
• US8772323B2
  申请人：——

  公开号：US8772323B2

  公开（公告）日：2014-07-08