1-(4-amino-2-fluoro-phenyl)-piperidin-4-one | 565459-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(4-amino-2-fluoro-phenyl)-piperidin-4-one
• 英文别名: 1-(4-amino-2-fluorophenyl)piperidin-4-one
• CAS: 565459-84-9
• 化学式: C₁₁H₁₃FN₂O
• 分子量: 208.235
• InChiKey: ASXGJOJWQWTHNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-amino-2-fluoro-phenyl)-piperidin-4-one 在 碳酸氢钠 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 3-[3-Fluoro-4-[4-[4-[4-[[1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-3-oxo-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]piperazin-1-yl]piperidin-1-yl]anilino]piperidine-2,6-dione
  参考文献：
  名称：

  [EN] WEE1 PROTEIN KINASE DEGRADATION AGENT AND USE THEREOF
  [FR] AGENT DE DÉGRADATION DE PROTÉINE KINASE WEE1 ET SON UTILISATION
  [ZH] WEE1蛋白激酶降解剂及其用途

  摘要：

  一种降解Wee1蛋白激酶的化合物或其药学可接受盐，以及其在治疗增殖性疾病中的用途。

  公开号：

  WO2023083194A1
• 作为产物：
  描述：

  1-(2-氟-4-硝基苯基)哌啶-4-酮 在 铁粉 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 生成 1-(4-amino-2-fluoro-phenyl)-piperidin-4-one
  参考文献：
  名称：

  [EN] WEE1 PROTEIN KINASE DEGRADATION AGENT AND USE THEREOF
  [FR] AGENT DE DÉGRADATION DE PROTÉINE KINASE WEE1 ET SON UTILISATION
  [ZH] WEE1蛋白激酶降解剂及其用途

  摘要：

  一种降解Wee1蛋白激酶的化合物或其药学可接受盐，以及其在治疗增殖性疾病中的用途。

  公开号：

  WO2023083194A1

文献信息

• NOVEL ANTIBACTERIAL COMPOUNDS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Das Jagattaran

  公开号：US20050113347A1

  公开（公告）日：2005-05-26

  The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. More particularly, the present invention relates to novel triazoles of the general formula (I) their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及一种新型三唑化合物，其化学式为（I），其衍生物，类似物，互变异构体，区域异构体，旋转异构体，立体异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化合物以及含有它们的制药组合物。更具体地，本发明涉及一种新型三唑化合物，其一般式为（I），其衍生物，类似物，互变异构体，区域异构体，旋转异构体，立体异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化合物以及含有它们的制药组合物。
• Novel antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
  申请人：Das Jagattaran

  公开号：US20050209223A1

  公开（公告）日：2005-09-22

  The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. More particularly, the present invention relates to novel triazoles of the general formula (I) their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及公式（I）的新型三唑类化合物及其衍生物、类似物、互变异构体、区域异构体、旋转异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物和含有它们的制药组合物。更特别地，本发明涉及一般公式（I）的新型三唑及其衍生物、类似物、互变异构体、区域异构体、旋转异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物和含有它们的制药组合物。
• Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them
  申请人：Das Jagattaran

  公开号：US06914058B2

  公开（公告）日：2005-07-05

  The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotammers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them. More particularly, the present invention relates to novel triazoles of the general formula (I) their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及一种新型三唑化合物的公式（I），它们的衍生物、类似物、互变异构体、区域异构体、转角异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和含有它们的制药组合物。更具体地说，本发明涉及一种新型三唑化合物的一般公式（I），它们的衍生物、类似物、互变异构体、区域异构体、转角异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和含有它们的制药组合物。
• [EN] TRIAZOLE DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] NOUVEAUX COMPOSES TRIAZOLIQUES, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：REDDYS LAB LTD DR

  公开号：WO2005035528A3

  公开（公告）日：2005-06-02
• NOVEL ANTIBACTERIAL COMPOUNDS:PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP1467977A1

  公开（公告）日：2004-10-20