1-allyl-isoquinoline | 100062-82-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 1-allyl-isoquinoline
• 英文别名: 1-Allyl-isochinolin；1-Prop-2-enylisoquinoline
• CAS: 100062-82-6
• 化学式: C₁₂H₁₁N
• 分子量: 169.226
• InChiKey: YFQNCNHULWPXTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异喹啉 在 乙醚 、 烯丙基溴化镁 作用下， 生成 1-allyl-isoquinoline
  参考文献：
  名称：

  Allylmagnesium Bromide as a Selective Nucleophile toward Aza-aromatic Heterocycles

  摘要：

  DOI：

  10.1021/ja01562a054

文献信息

• PROCESS FOR PRODUCTION OF DIALKYL CARBONATE AND DIOL IN INDUSTRIAL SCALE
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1961721A1

  公开（公告）日：2008-08-27

  It is an object of the present invention to provide a specific process that enables dialkyl carbonates and diols to be produced on an industrial scale of not less than 2 ton / hr and not less than 1.3 ton / hr respectively with high selectivity and high productivity stably for a prolonged period of time through a reactive distillation system of taking cyclic carbonates and aliphatic monohydric alcohols as starting materials, continuously feeding the starting materials into a continuous multi-stage distillation column in which a catalyst is present, and carrying out reaction and distillation simultaneously in the column. Although there have been many proposals regarding processes for the production of the dialkyl carbonates and the diols through a reactive distillation method, these have all been on a small scale and short operating time laboratory level, and there have been no disclosures whatsoever on a specific process or apparatus enabling mass production on an industrial scale. According to the present invention, there are provided a specific continuous multi-stage distillation column having a specified structure, and a production process using this continuous multi-stage distillation column, in which the dialkyl carbonates and the diols can be produced on an industrial scale of not less than 2 ton / hr and not less than 1.3 ton / hr respectively each with a selectivity of not less than 95%, preferably not less than 97%, more preferably not less than 99%, with a high yield stably for not less than 1000 hours, preferably not less than 3000 hours, more preferably not less than 5000 hours.

  本发明的目的是提供一种特定的工艺，通过反应蒸馏系统，以环状碳酸酯和脂肪族一元醇为原料，在连续多级蒸馏塔中连续供给原料，其中存在催化剂，并在塔内同时进行反应和蒸馏，从而使二烷基碳酸酯和二元醇能够以高选择性和高生产率稳定地在工业规模上生产，二者产量分别不低于2吨/小时和1.3吨/小时。尽管关于通过反应蒸馏方法生产二烷基碳酸酯和二元醇的工艺已有许多提议，但这些都是在小规模和短时间的实验室水平上进行的，对于能够在工业规模上进行大规模生产的特定工艺或设备没有任何披露。根据本发明，提供了一种具有特定结构的连续多级蒸馏塔，以及使用该连续多级蒸馏塔的生产工艺，其中二烷基碳酸酯和二元醇可以分别以不低于2吨/小时和1.3吨/小时的工业规模生产，且选择性不低于95%，优选不低于97%，更优选不低于99%，产量高且稳定，持续时间不低于1000小时，优选不低于3000小时，更优选不低于5000小时。
• INDUSTRIAL PROCESS FOR PRODUCTION OF HIGH-PURITY DIARYL CARBONATES
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1961731A1

  公开（公告）日：2008-08-27

  It is an object of the present invention to provide a specific process that enables a high-purity diaryl carbonate required for producing a high-quality high-performance aromatic polycarbonate to be produced industrially in a large amount (e.g. not less than 1 ton / hr) stably for a prolonged period of time (e.g. not less than 1000 hours, preferably not less than 3000 hours, more preferably not less than 5000 hours) from a cyclic carbonate and an aromatic monohydroxy compound. When producing a high-purity diaryl carbonate from a cyclic carbonate and an aromatic monohydroxy compound, the above object can be attained by carrying out a process of the present invention which comprises the steps of: (I) producing a dialkyl carbonate and a diol using a reactive distillation column having a specified structure; (II) producing a diaryl carbonate using two reactive distillation columns each having a specified structure; and (III) purifying the diaryl carbonate so as to obtain a high-purity diaryl carbonate.

  本发明的目的是提供一种特定工艺，使得可以在工业上大量稳定地生产所需用于生产高质量高性能芳香族聚碳酸酯的高纯度二芳基碳酸酯（例如，每小时不少于1吨），并且可以在较长时间内（例如，不少于1000小时，最好不少于3000小时，更好不少于5000小时）从环状碳酸酯和芳香族单羟基化合物中生产。当从环状碳酸酯和芳香族单羟基化合物生产高纯度二芳基碳酸酯时，可以通过执行本发明的工艺步骤来实现上述目的，该工艺步骤包括：（I）使用具有特定结构的反应精馏塔生产二烷基碳酸酯和二醇；（II）使用具有特定结构的两个反应精馏塔生产二芳基碳酸酯；和（III）纯化二芳基碳酸酯以获得高纯度二芳基碳酸酯。
• INDUSTRIAL PROCESS FOR PRODUCTION OF AROMATIC CARBONATE
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1961732A1

  公开（公告）日：2008-08-27

  It is an object of the present invention to provide a specific process that enables an aromatic carbonate required for producing a high-quality high-performance aromatic polycarbonate to be produced industrially in a large amount (e.g. not less than 1 ton / hr) stably for a prolonged period of time (e.g. not less than 1000 hours, preferably not less than 3000 hours, more preferably not less than 5000 hours) from a cyclic carbonate and an aromatic monohydroxy compound. When producing an aromatic carbonate from a cyclic carbonate and an aromatic monohydroxy compound, the above object can be attained by carrying out a step of: (I) producing a dialkyl carbonate and a diol using a reactive distillation column having a specified structure, and (II) producing the an aromatic carbonate using a first reactive distillation column having a specified structure.

  本发明的目的是提供一种特定的工艺，使得可以从环状碳酸酯和芳香单羟基化合物中稳定地大量（例如不少于1吨/小时）工业化生产所需用于生产高质量高性能芳香聚碳酸酯的芳香碳酸酯，且在较长时间内（例如不少于1000小时，更好地不少于3000小时，更好地不少于5000小时）。当从环状碳酸酯和芳香单羟基化合物生产芳香碳酸时，可以通过进行以下步骤实现上述目的：（I）使用具有特定结构的反应精馏塔生产二烷基碳酸酯和二元醇，以及（II）使用具有特定结构的第一反应精馏塔生产芳香碳酸。
• PROCESS FOR INDUSTRIAL PRODUCTION OF DIALKYL CARBONATES AND DIOLS
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1953131A1

  公开（公告）日：2008-08-06

  It is an object of the present invention to provide a specific process that enables a dialkyl carbonate and a diol to be produced on an industrial scale of not less than 2 ton / hr and not less than 1.3 ton / hr respectively with high selectivity and high productivity stably for a prolonged period of time through a reactive distillation system of taking a cyclic carbonate and an aliphatic monohydric alcohol as starting materials, continuously feeding the starting materials into a continuous multi-stage distillation column in which a catalyst is present, and carrying out reaction and distillation simultaneously in the column. Although there have been many proposals regarding processes for the production of the dialkyl carbonate and the diol through the reactive distillation method, these have all been on a small scale and short operating time laboratory level, and there have been no disclosures whatsoever on a specific process or apparatus enabling mass production on an industrial scale. According to the present invention, there is provided a specific continuous multi-stage distillation column having a specified structure, and a production process using this continuous multi-stage distillation column, according to which the dialkyl carbonate and the diol can be produced on an industrial scale of not less than 2 ton / hr and not less than 1.3 ton / hr respectively each with a selectivity of not less than 95%, preferably not less than 97%, more preferably not less than 99%, stably for not less than 1000 hours, preferably not less than 3000 hours, more preferably not less than 5000 hours.

  本发明的目的是提供一种特定的工艺，通过反应蒸馏系统，以环碳酸酯和脂肪族一元醇为原料，连续将原料进料到带有催化剂的连续多级蒸馏塔中，在该塔中同时进行反应和蒸馏，从而能够稳定地在工业规模下生产不低于每小时2吨和不低于每小时1.3吨的二烷基碳酸酯和二醇，且具有高选择性和高生产率，持续时间长。尽管关于通过反应蒸馏法生产二烷基碳酸酯和二醇的工艺已有许多提议，但这些都是在小规模和短时间的实验室水平上进行的，对于能够在工业规模下进行大规模生产的特定工艺或装置没有任何披露。根据本发明，提供了一种具有特定结构的连续多级蒸馏塔，以及使用该连续多级蒸馏塔的生产工艺，根据该工艺，二烷基碳酸酯和二醇可以分别以不低于每小时2吨和不低于每小时1.3吨的工业规模生产，且选择性不低于95%，更好地不低于97%，更好地不低于99%，稳定地持续时间不低于1000小时，更好地不低于3000小时，更好地不低于5000小时。
• PROCESS FOR PRODUCING HIGH-PURITY DIPHENYL CARBONATE ON AN INDUSTRIAL SCALE
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1964831A1

  公开（公告）日：2008-09-03

  It is an object of the present invention to provide a specific process that enables a high-purity diphenyl carbonate required for producing a high-quality high-performance aromatic polycarbonate to be produced industrially in a large amount (e.g. not less than 1 ton / hr) stably for a prolonged period of time (e.g. not less than 1000 hours, preferably not less than 3000 hours, more preferably not less than 5000 hours) from a cyclic carbonate and a phenol. When producing, from a cyclic carbonate and a phenol, a high-purity diphenyl carbonate required for producing a high-quality high-performance aromatic polycarbonate, the above object can be attained by carrying out a process according to the present invention which comprises steps of: (I) producing a dialkyl carbonate and a diol using a reactive distillation column having a specified structure; (II) producing a diphenyl carbonate using two reactive distillation columns each having a specified structure, and (III) obtaining a high-purity diphenyl carbonate from the diphenyl carbonate using a high boiling point material separating column A and a diphenyl carbonate purifying column B.

  本发明的目的是提供一种特定工艺，使得可以从环状碳酸酯和酚中稳定地大量（例如不少于1吨/小时）工业化生产所需用于生产高质量高性能芳香族聚碳酸酯的高纯度二苯碳酸酯，且生产时间持续较长（例如不少于1000小时，最好不少于3000小时，更好地不少于5000小时）。在从环状碳酸酯和酚中生产所需用于生产高质量高性能芳香族聚碳酸酯的高纯度二苯碳酸酯时，可以通过进行本发明的工艺步骤来实现上述目的，包括以下步骤：（I）使用具有特定结构的反应精馏塔生产二烷基碳酸酯和二元醇；（II）使用具有特定结构的两个反应精馏塔生产二苯碳酸酯；以及（III）通过使用高沸点物分离塔A和二苯碳酸酯纯化塔B从二苯碳酸酯中获得高纯度二苯碳酸酯。