4-(2-methoxyethoxymethoxy)phenol | 129543-57-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(2-methoxyethoxymethoxy)phenol
• 英文别名: p-[(2-methoxy)ethoxymethoxy]phenol
• CAS: 129543-57-3
• 化学式: C₁₀H₁₄O₄
• 分子量: 198.219
• InChiKey: VZZFYBDBXNWBGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  右旋环氧氯丙烷 、 4-(2-methoxyethoxymethoxy)phenol 在 氢氧化钾 作用下， 以 水 为溶剂， 反应 15.0h， 以58%的产率得到(S)-2-{[4-(2-methoxyethoxymethoxy)phenoxy]methyl}oxirane
  参考文献：
  名称：

  Discovery of novel acetanilide derivatives as potent and selective β3-adrenergic receptor agonists

  摘要：

  In the search for potent and selective human beta 3-adrenergic receptor (AR) agonists as potential drugs for the treatment of obesity and noninsulin-dependent (type II) diabetes a novel series of acetanilide-based analogues were prepared and their biological activities were evaluated at the human beta 3-, beta 2-, and beta 1-ARs. Among these compounds, 2-pyridylacetanilide (2f), pyrimidin-2-ylacetanilide (2u), and pyrazin-2-ylacetanilide (2v) derivatives exhibited potent agonistic activity at the beta 3-AR with functional selectivity over the beta 1- and beta 2-ARs. In particular, compound 2u was found to be the most potent and selective beta 3-AR agonist with an EC(50) value of 0.11 mu M and no agonistic activity for either the beta 1 - or beta 2-AR. In addition, 2f, 2u, and 2v showed significant hypoglycemic activity in a rodent diabetic model. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.01.022

文献信息

• 3-aryloxmethyl-cephalosporin derivatives, and their medical use
  申请人：Sankyo Company, Limited

  公开号：US05389626A1

  公开（公告）日：1995-02-14

  Compounds of formula (I): ##STR1## in which: R.sup.1 is hydrogen or acyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkoxy; and Ar is phenyl or substituted phenyl and pharmaceutically acceptable salts and esters thereof have valuable antibiotic activity, including against Methicillin-resistant strains of Staphylococcus. The invention also provides a process for preparing the compounds and methods and compositions using them.

  公式（I）的化合物：##STR1## 其中：R.sup.1是氢或酰基；R.sup.2是氢或C.sub.1 -C.sub.4烷氧基；Ar是苯基或取代苯基，其药用盐和酯具有有价值的抗生素活性，包括对金黄色葡萄球菌耐甲氧西林菌株的活性。本发明还提供了制备这些化合物的方法以及利用它们的方法和组合物。
• 3-Aryloxymethyl-cephalosporin derivatives, their preparation and their medical use
  申请人：Sankyo Company Limited

  公开号：EP0363223A2

  公开（公告）日：1990-04-11

  Compounds of formula (I); [in which: R¹ is hydrogen or acyl; R² is hydrogen or C₁ - C₄ alkoxy; and Ar is phenyl or substituted phenyl] and pharmaceutically acceptable salts and esters thereof have valuable antibiotic activity, including against Methicillin-resistant strains of Staphylococcus. The invention also provides a process for preparing the compounds and methods and compositions using them.

  式(I)化合物； 其中R¹ 是氢或酰基；R² 是氢或 C₁ - C₄ 烷氧基；Ar 是苯基或取代苯基]及其药学上可接受的盐和酯具有宝贵的抗生素活性，包括抗耐甲氧西林葡萄球菌菌株的活性。本发明还提供了制备这些化合物的工艺以及使用它们的方法和组合物。
• NOVEL INTERMEDIATES USEFUL FOR THE PREPARATION OF COENZYMES, PROCESS FOR THE PREPARATION OF NOVEL INTERMEDIATES AND AN IMPROVED PROCESS FOR THE PREPARATION OF COENZYMES
  申请人：Nicholas Piramal India Limited

  公开号：EP1910263A2

  公开（公告）日：2008-04-16
• US5389626A
  申请人：——

  公开号：US5389626A

  公开（公告）日：1995-02-14
• US5932196A
  申请人：——

  公开号：US5932196A

  公开（公告）日：1999-08-03