1-Phenyl-4-m-hydroxyphenyl-pentan | 69026-13-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-Phenyl-4-m-hydroxyphenyl-pentan
• 英文别名: 3-(1-Methyl-4-phenylbutyl)-phenol；2-(m-Hydroxyphenyl)-5-phenylpentan；2-(3-Hydroxyphenyl)-5-phenylpentane；3-(5-phenylpentan-2-yl)phenol
• CAS: 69026-13-7
• 化学式: C₁₇H₂₀O
• 分子量: 240.345
• InChiKey: YWJUCMXJNIYNNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(3-methoxyphenyl)-5-phenylpentane 在 吡啶盐酸盐 作用下， 以 盐酸 为溶剂， 生成 1-Phenyl-4-m-hydroxyphenyl-pentan
  参考文献：
  名称：

  Hydroxyalkyl and oxoalkyl substituted phenols as analgesics and sedatives

  摘要：

  用于药理学和药用目的的化合物，其分子式为##STR1##其中R为H，C.sub.1 -C.sub.5烷酰基；R.sub.1为H，苄基，C.sub.1 -C.sub.5烷酰基，P(O)(OH).sub.2，--CO(CH.sub.2).sub.2 COOH或一种碱性酰基；R.sub.2和R.sub.4中的每一个为H，C.sub.1 -C.sub.6烷基，苯基，吡啶基或(CH.sub.2).sub.y C.sub.6 H.sub.5；y为1-4；R.sub.3为H或CH.sub.3；Z为C.sub.1 -C.sub.13亚烷基或--(alk.sub.1).sub.m--O--(alk.sub.2).sub.n--；(alk.sub.1)和(alk.sub.2)中的每一个为C.sub.1 -C.sub.13亚烷基，但要求(alk.sub.1)加上(alk.sub.2)的碳原子总数不大于13；m和n中的每一个为0或1；W为H，吡啶基，苯基，氟苯基或氯苯基；其中间体以及其制备和使用方法。

  公开号：

  US04283569A1

文献信息

• 3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives
  申请人：Pfizer Inc.

  公开号：US04147872A1

  公开（公告）日：1979-04-03

  Azacycloalkanes, and derivatives thereof, including unsaturated analogs, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.

  Azacycloalkanes，及其衍生物，包括不饱和类似物，每个分子在3位有一个2-羟基-4-取代苯基，其中4位的取代基是烷基，可以有氧原子作为链的一部分，或者是芳基烷基，可以有氧原子作为烷基链的一部分，它们用于药理和医学目的，中间体以及它们的制备方法。
• 3-[2-Hydroxy-4-(substituted)phenyl]azacycloalkanols and derivatives
  申请人：Pfizer Inc.

  公开号：US04387229A1

  公开（公告）日：1983-06-07

  Azacycloalkanes, and derivatives thereof, including unsaturated analogs, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.

  Azacycloalkanes及其衍生物，包括不饱和类似物，每个在3位置具有2-羟基-4-取代苯基基团的化合物，其中4位置取代基是可以作为链的一部分具有氧原子的烷基或可以作为烷基链的一部分具有氧原子的芳基烷基，它们用于药理和医学目的，其中间体和制备它们的过程。
• 3-(2-Hydroxy-4-(substituted)phenyl)-cycloalkanone and cycloalkanol
  申请人：Pfizer Inc.

  公开号：US04391827A1

  公开（公告）日：1983-07-05

  Cycloalkanones, cycloalkanols and unsaturated analogs thereof, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.

  环烷酮，环烷醇及其不饱和类似物，每种化合物在3位具有2-羟基-4-取代苯基，其中4位取代基是烷基，可以将氧原子作为链的一部分，或是芳基烷基，可以将氧原子作为烷基链的一部分。它们用于药理学和医学目的，其中间体以及制备它们的过程。
• 9-Hydroxyhexahydrodibenzo[b,d]pyrans,
  申请人：Pfizer Inc.

  公开号：US04165323A1

  公开（公告）日：1979-08-21

  9-Hydroxyhexahydrodibenzo[b,d]pyrans, 1-substituted-9-hydroxyhexahydrodibenzo[b,d]pyrans wherein the substituent is hydrogen, methyl, hydroxymethyl, formyl, carboxy, carbamyl, amino, mono- and di-alkylamino, alkanoylamino, phenalkylsulfonamido or alkylsulfonamido, and the corresponding 9-ketones, all of which are useful as CNS agents, especially as analgesics and tranquilizers, intermediates therefor and processes for their preparation.

  9-羟基六氢二苯并[b,d]吡喃，1-取代-9-羟基六氢二苯并[b,d]吡喃，其中取代基为氢、甲基、羟甲基、甲酰基、羧基、氨基、单-和双-烷基氨基、烷酰氨基、苯基烷磺酰胺基或烷基磺酰胺基，以及相应的9-酮，均可用作中枢神经系统药物，特别是作为镇痛剂和镇静剂，其中间体及其制备方法。
• 9-Hydroxyhexahydrodibeno[b,d]pyrans,
  申请人：Pfizer Inc.

  公开号：US04235913A1

  公开（公告）日：1980-11-25

  9-Hydroxyhexahydrodibenzo[b,d]pyrans, 1-substituted-9-hydroxyhexahydrodibenzo[b,d]pyrans wherein the substituent is hydrogen, methyl, hydroxymethyl, formyl, carboxy, carbamyl, amino, mono- and di-alkylamino, alkanoylamino, phenalkylsulfonamido or alkylsulfonamido, and the corresponding 9-ketones, all of which are useful as CNS agents, especially as analgesics and tranquilizers,intermediates therefor and processes for their preparation.

  9-羟基六氢二苯并[b,d]吡喃，1-取代-9-羟基六氢二苯并[b,d]吡喃，其中取代基为氢、甲基、羟甲基、甲酰基、羧基、氨基、单烷基和双烷基氨基、烷酰氨基、苯基烷磺酰胺基或烷基磺酰胺基，以及相应的9-酮，均可作为CNS剂，特别是作为镇痛剂和镇静剂，其中间体和制备方法。