4--anilin | 2359-61-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4--anilin
• 英文别名: N-methyl-N-propyl-p-phenylenediamine；N-Methyl-N-propyl-p-phenylendiamin；N1-Methyl-N1-propyl-1,4-benzenediamine；4-N-methyl-4-N-propylbenzene-1,4-diamine
• CAS: 2359-61-7
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: ACPHRXVPNJUGLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4--anilin 在 盐酸 、 三氯氧磷 作用下， 生成 (4-chloro-2-methyl-[6]quinolyl)-methyl-propyl-amine
  参考文献：
  名称：

  639.寻找新的锥虫病。第二部分 4-氨基-6-二烷基氨基喹哪啶

  摘要：

  DOI：

  10.1039/jr9560003293
• 作为产物：
  描述：

  N-methyl-4-nitroso-N-propyl-aniline 在 盐酸 、 锌 作用下， 生成 4--anilin
  参考文献：
  名称：

  Chemical Constitution, Electrochemical, Photographic and Allergenic Properties of p-Amino-N-dialkylanilines¹

  摘要：

  DOI：

  10.1021/ja01151a037

文献信息

• Hydrogenation of aromatic amines to alicyclic amines using a lithium aluminate-based catalyst
  申请人：Vedage Ananda Gamini

  公开号：US20070066849A1

  公开（公告）日：2007-03-22

  The present invention relates to processes for the catalytic hydrogenation of aromatic amines to their acyclic counterparts using a ruthenium catalyst on a lithium aluminate support. The hydrogenation process comprises contacting an aromatic amine with hydrogen in the presence of a ruthenium catalyst under temperature and pressure conditions suitable to effect ring hydrogenation. The process is especially useful for hydrogenating aniline to cyclohexylamine.

  本发明涉及使用锂铝酸盐支撑上的钌催化剂进行芳香胺的催化氢化反应，将其转化为其非环状对应物的过程。氢化过程包括在适宜于环氢化的温度和压力条件下，在钌催化剂存在下将芳香胺与氢气接触。该过程特别适用于将苯胺氢化为环己胺。
• HETEROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：ACEA BIOSCIENCES INC.

  公开号：US20150133457A1

  公开（公告）日：2015-05-14

  The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

  本发明涉及制药化合物、组合物和方法，特别是涉及用于治疗和/或预防增殖障碍、癌症、肿瘤、炎症性疾病、自身免疫疾病、银屑病、干眼症或免疫相关疾病的组合物和方法，以及在某些实施方式中与激酶失调相关的疾病或疾病，例如但不限于EGFR（包括HER）、Alk、PDGFR、BLK、BMX/ETK、FLT3（D835Y）、ITK、TEC、TXK、BTK或JAK及其相应的通路。
• IMIDAZOPYRIDINE DERIVATIVE COMPOUNDS AND USE OF SAME
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP3907225A1

  公开（公告）日：2021-11-10

  One aspect of the present invention provides a compound selected from among a compound of chemical formula 1 having lysine-specific demethylase-1 (LSD1) inhibitory activity, and a tautomer, a stereoisomer, and a solvate thereof, and pharmaceutically acceptable salts of the aforementioned components, and said compound is effective in the prevention or treatment of diseases caused by abnormal activation of LSD1.

  本发明的一个方面提供了一种选自具有赖氨酸特异性去甲基化酶-1（LSD1）抑制活性的化学式1化合物及其同系物、立体异构体和溶解物的化合物，以及上述组分的药学上可接受的盐，所述化合物可有效预防或治疗由LSD1异常激活引起的疾病。
• Silica-based zinc catalysts, their preparation and use in the alkoxycarbonylation of amines
  申请人：Covestro Deutschland AG

  公开号：US10807084B2

  公开（公告）日：2020-10-20

  The present invention relates to silica-based heterogeneous zinc compounds which are suitable as catalysts in the reaction of amines with dialkyl carbonates to produce carbamates. The catalysts have the formula [SiO2]—CH2—CHR—X—COOZn[Y], wherein [SiO2] represents a silica carrier selected from the group consisting of ordered mesoporous silica and irregular amorphous narrow pore silica, R represents a moiety selected from the group consisting of hydrogen, —CH3, and —CH2CH3, preferably hydrogen, X is an aliphatic chain of 2 to 11 carbon atoms that optionally comprises ether moieties and [Y] represents a mono anion. The invention is also directed towards a method for the preparation of the aforementioned compounds and towards method for the alkoxycarbonylation of amines.

  本发明涉及硅基异质锌化合物，该化合物适合作为胺与二烷基碳酸盐反应生成氨基甲酸酯的催化剂。该催化剂具有式[SiO2]-CH2-CHR-X-COOZn[Y]，其中[SiO2]代表从有序介孔二氧化硅和不规则无定形窄孔二氧化硅组成的组中选出的二氧化硅载体，R代表从氢、-CH3和-CH2CH3组成的组中选出的分子，优选氢，X是2至11个碳原子的脂肪族链，可选择包括醚分子，[Y]代表单阴离子。本发明还涉及上述化合物的制备方法和胺的烷氧基羰基化方法。
• Chemical Constitution, Electrochemical, Photographic and Allergenic Properties of p-Amino-N-dialkylanilines¹
  作者：R. L. Bent、J. C. Dessloch、F. C. Duennebier、D. W. Fassett、D. B. Glass、T. H. James、D. B. Julian、W. R. Ruby、J. M. Snell、J. H. Sterner、J. R. Thirtle、P. W. Vittum、A. Weissberger

  DOI：10.1021/ja01151a037

  日期：1951.7