alatusol A | 1578237-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: alatusol A
• 英文别名: [(2R,3R)-2-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-3-methoxypropyl] acetate
• CAS: 1578237-39-4
• 化学式: C₁₃H₁₈O₆
• 分子量: 270.282
• InChiKey: XHNRQSCQZUNDQZ-DGCLKSJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  alatusol A 、 (R)-methoxytrifluoromethylphenylacetyl chloride 在 吡啶 、 4-二甲氨基吡啶 作用下， 生成
  参考文献：
  名称：

  Phenolic Constituents from the Twigs of Euonymus alatus and Their Cytotoxic and Anti-inflammatory Activity

  摘要：

  A bioassay-guided fractionation and chemical investigation of the MeOH extract of the twigs of Euonymus alatus resulted in the isolation and identification of five new phenolic compounds, named alatusols A-E (1-5), together with six known compounds (6-11). The structures of these new compounds were elucidated through spectral analysis, including extensive 2D-NMR data, and their absolute configurations were determined by the modified Mosher's method. Compounds 1-3 and 7-9 showed consistent cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values of 15.20-29.81 mu M. In addition, compounds 5 and 7 inhibited nitric oxide production in lipopolysaccharide-activated BV-2 cells with IC50 values of 22.77 and 32.52 mu M, respectively.

  DOI：

  10.1055/s-0032-1328286