2-Methyl-1-naphthalen-1-yl-4,5,6,7-tetrahydro-1H-indole | 827019-58-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Methyl-1-naphthalen-1-yl-4,5,6,7-tetrahydro-1H-indole
• 英文别名: 2-Methyl-1-(naphthalen-1-yl)-4,5,6,7-tetrahydro-1H-indole；2-methyl-1-naphthalen-1-yl-4,5,6,7-tetrahydroindole
• CAS: 827019-58-9
• 化学式: C₁₉H₁₉N
• 分子量: 261.367
• InChiKey: UJZZVLCFNSDDTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1-吡咯烷-1-环己烯 在 对甲苯磺酸 、 三乙胺 作用下， 以 1,4-二氧六环 、 甲苯 为溶剂， 反应 9.0h， 生成 2-Methyl-1-naphthalen-1-yl-4,5,6,7-tetrahydro-1H-indole
  参考文献：
  名称：

  One-pot synthesis of N-substituted 2-methyl-4,5,6,7-tetrahydroindole derivatives

  摘要：

  We describe the preliminary results of one-pot syntheses of various N-substituted 2-methyl-4,5,6,7-tetrahydroindole derivatives from 2-(2-bromoailyl)cyclohexanone and the corresponding primary amines in good yields. Aliphatic amines were directly converted to tetrahydroindoles, whereas aromatic amines needed an extra base treatment step to complete the transformation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.10.145

文献信息

• One-pot synthesis of N-substituted 2-methyl-4,5,6,7-tetrahydroindole derivatives
  作者：Cihangir Tanyeli、İdris M. Akhmedov、Emre Y. Yazıcıoğlu

  DOI：10.1016/j.tetlet.2004.10.145

  日期：2004.12

  We describe the preliminary results of one-pot syntheses of various N-substituted 2-methyl-4,5,6,7-tetrahydroindole derivatives from 2-(2-bromoailyl)cyclohexanone and the corresponding primary amines in good yields. Aliphatic amines were directly converted to tetrahydroindoles, whereas aromatic amines needed an extra base treatment step to complete the transformation. (C) 2004 Elsevier Ltd. All rights reserved.