bis(4-diphenylaminophenyl)fumaronitrile | 1191424-76-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis(4-diphenylaminophenyl)fumaronitrile
• 英文别名: 2,3-bis(4-(diphenylamino)phenyl)fumaronitrile；2,3-bis[4-(N-phenylanilino)phenyl]but-2-enedinitrile
• CAS: 1191424-76-6
• 化学式: C₄₀H₂₈N₄
• 分子量: 564.689
• InChiKey: STBBTSRTHKHPPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  44
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis(4-diphenylaminophenyl)fumaronitrile 在 氨 、 sodium 作用下， 以 二乙二醇二甲醚 为溶剂， 生成 3,4-bis(4-diphenylaminophenyl)pyrroline-2,5-diimine
  参考文献：
  名称：

  磷 (V) 四氮杂卟啉在近红外区域具有强而宽的 CT 波段

  摘要：

  在磷四氮杂卟啉 (PTAP) 中，Q 带和电荷转移 (CT) 带是其激发态之间构型相互作用的结果。在此概念的基础上，通过引入八个二苯氨基苯基（dPAP）基团，合理设计并实现了在近红外区域具有强烈、宽CT谱带的PTAP。磁圆二色性 (MCD) 光谱和理论计算支持了 CT 和 Q 带在上升能量中的顺序。在深近红外区域也发现了强烈的双光子吸收。

  DOI：

  10.1021/acs.orglett.4c00298

文献信息

• Biocompatible Nanoparticles with Aggregation Induced Emission Characteristics as Fluorescent Bioprobes and Methods of Using the Same for In Vitro and In Vivo Imaging
  申请人：Tang Benzhong

  公开号：US20140328764A1

  公开（公告）日：2014-11-06

  The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.

  有机荧光化合物构成的发光生物探针的发展，其具有聚集诱导发射（AIE）特性，生产方法以及它们在体外和体内生物成像方面的实际应用。
• Biocompatible nanoparticles with aggregation induced emission characteristics as fluorescent bioprobes and methods of using the same for in vitro and in vivo imaging
  申请人：Tang Benzhong

  公开号：US10753941B2

  公开（公告）日：2020-08-25

  The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.

  开发由具有聚集诱导发射（AIE）特性的有机荧光化合物组成的荧光生物探针、生产这种探针的方法及其在体外和体内生物成像中的实际应用。
• [EN] BIOCOMPATIBLE NANOPARTICLES WITH AGGREGATION INDUCED EMISSION CHARACTERISTICS AS FLUORESCENT BIOPROBES AND METHODS OF USING THE SAME FOR IN VITRO AND IN VIVO IMAGING<br/>[FR] NANOPARTICULES BIOCOMPATIBLES PRÉSENTANT DES CARACTÉRISTIQUES D'ÉMISSION INDUITES PAR L'AGRÉGATION EN TANT QUE BIOSONDES FLUORESCENTES, ET PROCÉDÉS D'UTILISATION DE CELLES-CI POUR UNE IMAGERIE IN VITRO ET IN VIVO
  申请人：UNIV HONG KONG SCIENCE & TECHN

  公开号：WO2013029340A1

  公开（公告）日：2013-03-07

  The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.
• [EN] A MULTIMODAL FLUORESCENT PROBE<br/>[FR] SONDE FLUORESCENTE MULTIMODALE
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2017176216A1

  公开（公告）日：2017-10-12

  This invention relates to a nanoparticle comprising a fluorophore, an amphiphilic copolymer and a cyclic chelating agent, wherein the fluorophore and amphiphilic copolymer form a nanodot core, and wherein the cyclic chelating agent is conjugated onto the nanodot core. In particular, the fluorophore is selected from the group consisting of 2,3-bis[4- (diphenylamino)phenyl]fumaronitrile (TPAFN), 2,3-bis(4-(phenyl(4-(1,2,2-triphenylvinyl)phenyl)amino)phenyl) fumaronitrile (TPETPAFN), tetraphenylethylene (TPE); the amphiphilic copolymer is selected from 1,2-distearoyl-sn- glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000], 1,2-distearoyl-sn-glycero-3- phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000]; and the cyclic chelating agent is 2,2',2"-(10-(2-((2,5- dioxopyrrolidin-1 -yl)oxy)-2-oxoethyl)-1,4,7, 10-tetraazacyclododecane-1,4,7-triyl)triacetic acid. The invention also relates to a method of preparing such a nanoparticle, the use of such a nanoparticle for vascular imaging and a method for in vivo imaging of blood vessels using such nanoparticles.