(反,反)-1-溴-2,5-双(4-羟基)乙烯基苯 | 872201-12-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: (反,反)-1-溴-2,5-双(4-羟基)乙烯基苯
• 英文名称: K114
• 英文别名: (E,E)-1-bromo-2,5-bis-(4-hydroxystyryl)benzene；4-[(E)-2-[3-bromo-4-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl]ethenyl]phenol
• CAS: 872201-12-2
• 化学式: C₂₂H₁₇BrO₂
• 分子量: 393.28
• InChiKey: OXPHQQMZTXMEGO-RJTULKDBSA-N

物化性质

• 沸点：
  563.0±39.0 °C(Predicted)
• 密度：
  1.462±0.06 g/cm3(Predicted)
• 溶解度：
  DMSO：可溶，>10mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

制备方法与用途

生物活性

K114，一种刚果红染料类似物，与淀粉样纤维 (amyloid fibrils) 紧密结合，其 EC50 值为 20-30 nM。K114 是一种高效的精液源性病毒感染增强剂 (SEVI) 检测剂。

体外研究

K114's unusually low buffer fluorescence is due to self-quenching in sedimentable aggregates or micelles which upon interacting with amyloid fibrils undergo an enhancement in fluorescence intensity and shifts in the excitation and emission spectra.

反应信息

• 作为产物：
  描述：

  2-Bromo-1,4-bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzene 在 三溴化硼 作用下， 生成 (反,反)-1-溴-2,5-双(4-羟基)乙烯基苯
  参考文献：
  名称：

  Zhuang, Z.-P.; Kung, M.-P.; Hou, C., Journal of labelled compounds and radiopharmaceuticals, 2001, vol. 44, p. S236 - S238

  摘要：

  DOI：

文献信息

• MULTI-TARGETING AGENTS FOR ALZHEIMER'S DISEASE THERAPY
  申请人：The Regents of the University of California

  公开号：US20200171016A1

  公开（公告）日：2020-06-04

  The disclosure provides for multi-targeting agents that assist in the targeted removal of amyloid beta plaques from the brain and surrounding vasculature of subject's with Alzheimer's disease, and methods of treatment thereof.

  该披露提供了一种多靶向药剂，可帮助定向清除患有阿尔茨海默病的受试者大脑和周围血管系统中的淀粉样蛋白斑块，并提供了相应的治疗方法。
• MOLECULAR PROBES FOR DETECTING LIPID COMPOSITION
  申请人：Case Western Reserve University

  公开号：US20140079635A1

  公开（公告）日：2014-03-20

  A method of detecting myelin in a subject includes administering to the subject a molecular probe that includes a fluorescent trans stilbene derivative and detecting the amount or distribution of the molecular probe in a tissue of interest of the subject.

  一种检测受试者髓鞘的方法，包括向受试者施加一种分子探针，该探针包括一种荧光转-史蒂本衍生物，并检测受试者感兴趣的组织中分子探针的数量或分布。
• Neurofibromatoses therapeutic agents and screening for same
  申请人：Fernandez-Valle Cristina

  公开号：US10105351B2

  公开（公告）日：2018-10-23

  Disclosed herein are methods of treating a patient at risk of developing or having a neurofibromatosis or a sporadic schwannoma. In exemplary embodiments, the method involves administering to a subject in need an effective amount of a modulator of a target related to neurofibromatosis. Also disclosed are screening assays involving the implementation of Merlin-null Schwann cells, and to compounds identified using same.

  本文公开了治疗有患神经纤维瘤病或散发性分裂瘤风险的患者的方法。在示例性实施方案中，该方法涉及向有需要的受试者施用有效量的神经纤维瘤病相关靶点的调节剂。还公开了涉及实施Merlin-null许旺细胞的筛选试验，以及利用这些试验鉴定的化合物。
• Characterization of subvisible particles using a particle analyzer
  申请人：Baxalta Incorporated

  公开号：US10274500B2

  公开（公告）日：2019-04-30

  The present specification discloses methods of characterizing a population of particles using a particle analyzer. Particles may be characterized by size, absolute number, whether the particle is non-proteinaceous or proteinaceous, whether a proteinaceous particle has or lacks a certain physical property, or any combination thereof.

  本说明书公开了使用颗粒分析仪表征颗粒群的方法。颗粒可以通过大小、绝对数量、颗粒是非蛋白质还是蛋白质、蛋白质颗粒是否具有或缺乏某种物理特性或它们的任意组合来表征。
• In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes
  申请人：McKinnon J. Stuart

  公开号：US20050214222A1

  公开（公告）日：2005-09-29

  In vivo imaging may be used to assess a condition (e.g., a state of glaucoma or a state of ocular hypertension) of an eye of a living animal. A dye may be intravenously injected into the living animal. The dye may bind to amyloid in the nervous system of the animal. Images may be taken of a retina, an optic nerve head, an optic nerve, the lateral geniculate nucleus, and/or the visual cortex. Images may be taken using methods such as fluorescent angiography, magnetic resonance imaging, computed tomography, positron emission tomography, and/or single photon emission computed tomography. The condition of the eye and/or retinal ganglion cells in the eye may be assessed from one or more of the images. The condition of the eye may be assessed based on the presence of amyloid in one or more of the images.

  体内成像可用于评估活体动物眼睛的状况（如青光眼或眼压过高）。活体动物可静脉注射一种染料。染料可与动物神经系统中的淀粉样蛋白结合。可拍摄视网膜、视神经头、视神经、外侧膝状核和/或视觉皮层的图像。可使用荧光血管造影术、磁共振成像、计算机断层扫描、正电子发射断层扫描和/或单光子发射计算机断层扫描等方法拍摄图像。眼睛和/或眼睛中视网膜神经节细胞的状况可通过一张或多张图像进行评估。可根据一张或多张图像中是否存在淀粉样蛋白来评估眼睛的状况。