6-(5-(dimethylamino)naphthalene-1-sulfonamido)-N-hydroxyhexanamide | 1161600-87-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-(5-(dimethylamino)naphthalene-1-sulfonamido)-N-hydroxyhexanamide
• 英文别名: 6-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-N-hydroxyhexanamide
• CAS: 1161600-87-8
• 化学式: C₁₈H₂₅N₃O₄S
• 分子量: 379.48
• InChiKey: IAFMTZMOWYBUMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-(benzyloxy)-6-(5-(dimethylamino)naphthalene-1-sulfonamido)hexanamide 在 palladium 10% on activated carbon 氢气 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 以94%的产率得到6-(5-(dimethylamino)naphthalene-1-sulfonamido)-N-hydroxyhexanamide
  参考文献：
  名称：

  [EN] HISTONE DEACETYLASE INHIBITORS
  [FR] INHIBITEURS DE L'HISTONE DÉACÉTYLASE

  摘要：

  描述了新型组蛋白去乙酰化酶抑制剂，包括新型荧光组蛋白去乙酰化酶抑制剂。提供了制备和使用这些抑制剂的方法，例如用于治疗癌症。

  公开号：

  WO2009079375A1

文献信息

• HISTONE DEACETYLASE INHIBITORS
  申请人：Brown Milton L.

  公开号：US20100317739A1

  公开（公告）日：2010-12-16

  Novel histone deacetylase inhibitors, including novel fluorescent histone deacetylase inhibitors, are described. Methods for making and using the same, e.g., to treat cancer, are provided.

  本文描述了新型组蛋白去乙酰化酶抑制剂，包括新型荧光组蛋白去乙酰化酶抑制剂。提供了制备和使用这些抑制剂的方法，例如用于治疗癌症。
• METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE
  申请人：Design Therapeutics, Inc.

  公开号：US20210238226A1

  公开（公告）日：2021-08-05

  The present disclosure relates to compounds and methods for modulating the expression of dmpk, atxn1, atxn2, atxn3, cacna1a, atxn7, ppp2r2br tbp, htt, jph3r ar, or atn1 and treating diseases and conditions in which dmpk, atxn1, atxn2, atxn3, cacna1a, atxn1, ppp2r2b, tbp, htt, jph3, ar, or atn1 plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence CAG or CTG; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence CAG or CTG; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.
• US8293513B2
  申请人：——

  公开号：US8293513B2

  公开（公告）日：2012-10-23