(4-Bromonaphthalen-2-yl)-(5-ethylbenzo-[b]thiophen-2-yl)methanol | 874357-32-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4-Bromonaphthalen-2-yl)-(5-ethylbenzo-[b]thiophen-2-yl)methanol
• 英文别名: (4-Bromo-naphthalen-2-yl)-(5-ethylbenzo[b]-thiophen-2-yl)methanol；(4-bromonaphthalen-2-yl)-(5-ethyl-1-benzothiophen-2-yl)methanol
• CAS: 874357-32-1
• 化学式: C₂₁H₁₇BrOS
• 分子量: 397.335
• InChiKey: WLFVXEUDZFVCQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  48.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-Bromonaphthalen-2-yl)-(5-ethylbenzo-[b]thiophen-2-yl)methanol 在 三乙基硅烷 、 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以62%的产率得到2-(4-Bromonaphthalen-2-ylmethyl)-5-ethylbenzo[b]thiophene
  参考文献：
  名称：

  EP1803721

  摘要：

  公开号：
• 作为产物：
  描述：

  4-溴-2-萘甲醛 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.58h， 以90%的产率得到(4-Bromonaphthalen-2-yl)-(5-ethylbenzo-[b]thiophen-2-yl)methanol
  参考文献：
  名称：

  EP1803721

  摘要：

  公开号：

文献信息

• Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes
  申请人：Matsuoka Hiroharu

  公开号：US20080319047A1

  公开（公告）日：2008-12-25

  The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R 1 to R 4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.

  本发明提供了一种葡萄糖醇衍生物，具有降低血糖水平的功能，并具有药物所需的优良性质，例如持久的药物活性；以及用于预防或治疗由高血糖引起的疾病，例如糖尿病、糖尿病并发症和肥胖症的药物组合物。该衍生物是由式(I)表示的化合物：其中m是在1-3之间选择的整数；R1至R4各自独立地是可选的取代烷基等；Ar1是可选的取代萘基；A是可选的取代杂环芳基、该化合物的前药或其药学上可接受的盐。还提供了含有该化合物的药物、药物组合物等。
• Glucitol derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US07943748B2

  公开（公告）日：2011-05-17

  The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R1 to R4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.

  本发明提供了一种葡萄糖醇衍生物，具有降低血糖水平的功能，并具有药物所需的优良特性，例如长效药物活性；以及用于预防或治疗由高血糖引起的疾病，例如糖尿病、糖尿病并发症和肥胖症的药物组合物。该衍生物是由式（I）表示的化合物：其中m是在1-3之间选择的整数；R1到R4各自独立地是可选的取代烷基等；Ar1是可选的取代萘基；A是可选的取代杂环基，该化合物的前药物或其药学上可接受的盐。还提供了含有该化合物的药物、药物组合物等。
• NOVEL GLUCITOL DERIVATIVE, PRODRUG THEREOF AND SALT THEREOF, AND THERAPEUTIC AGENT CONTAINING THE SAME FOR DIABETES
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1803721A1

  公开（公告）日：2007-07-04

  The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R1 to R4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.

  本发明提供了一种葡萄糖醇衍生物，该衍生物具有降低血糖水平的功能，并具有药物所需的优越性能，如持久的药物活性；还提供了一种药物组合物，用于预防或治疗由高血糖引起的疾病，如糖尿病、糖尿病并发症和肥胖症。衍生物是由式 (I) 所代表的化合物： 其中 m 是选自 1-3 的整数；R1 至 R4 各自独立地是任选取代的烷基等；Ar1 是任选取代的萘基；A 是任选取代的杂芳基、该化合物的原药或二者的药学上可接受的盐。此外，还提供了各自含有该化合物的药物、药物组合物等。
• US7943748B2
  申请人：——

  公开号：US7943748B2

  公开（公告）日：2011-05-17
• EP1803721
  申请人：——

  公开号：——

  公开（公告）日：——