(2-bromo-4-isopropyl-phenyl)-[7-(2-methoxy-ethyl)-4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine | 864669-86-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: (2-bromo-4-isopropyl-phenyl)-[7-(2-methoxy-ethyl)-4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine
• 英文别名: (2-bromo-4-isopropyl-phenyl)-[7-(2-methoxy-ethyl)-4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2-yl]-amine；N-(2-bromo-4-propan-2-ylphenyl)-7-(2-methoxyethyl)-4-methyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-amine
• CAS: 864669-86-3
• 化学式: C₁₉H₂₅BrN₄O
• 分子量: 405.338
• InChiKey: XZWXGVBJQHHDNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  50.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2-bromo-4-isopropyl-phenyl)-[7-(2-methoxy-ethyl)-4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine 在 manganese dioxide silica gel 、 methanol-dichloromethane 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 以to give (2-bromo-4-isopropyl-phenyl)-[7-(2-methoxy-ethyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine (0.31 g)的产率得到(2-bromo-4-isopropyl-phenyl)-[7-(2-methoxy-ethyl)-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine
  参考文献：
  名称：

  Pyrrolopyrimidine Derivatives

  摘要：

  根据本发明，提供了一种CRF受体拮抗剂，作为治疗或预防CRF参与的疾病的药物，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、斑秃、肠易激综合征、睡眠障碍、癫痫、皮炎、精神分裂症、疼痛等。以下式[I]所表示的吡咯吡嘧啶衍生物对CRF受体具有高亲和力，并对CRF参与的疾病有效。

  公开号：

  US20070270588A1
• 作为产物：
  描述：

  (2-bromo-4-isopropyl-phenyl)-[4-chloro-5-(2-chloro-ethyl)-6-methyl-pyrimidin-2-yl]-amine 、 2-甲氧基乙胺 在 silica gel 、 methanol-dichloromethane 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 以to give (2-bromo-4-isopropyl-phenyl)-[7-(2-methoxy-ethyl)-4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2-yl]-amine (3.6 g)的产率得到(2-bromo-4-isopropyl-phenyl)-[7-(2-methoxy-ethyl)-4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl]-amine
  参考文献：
  名称：

  Pyrrolopyrimidine Derivatives

  摘要：

  根据本发明，提供了一种CRF受体拮抗剂，作为治疗或预防CRF参与的疾病的药物，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、斑秃、肠易激综合征、睡眠障碍、癫痫、皮炎、精神分裂症、疼痛等。以下式[I]所表示的吡咯吡嘧啶衍生物对CRF受体具有高亲和力，并对CRF参与的疾病有效。

  公开号：

  US20070270588A1

文献信息

• [EN] PYRROLOPYRIMIDINE DERIVATIVES<br/>[FR] DÉRIVÉS PYRROLOPYRIMIDINE
  申请人：TAISHO PHARMA CO LTD

  公开号：WO2005085253A1

  公开（公告）日：2005-09-15

  According to the present invention, there is provided an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastro-intesinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine derivative represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  根据本发明，提供了一种针对CRF受体的拮抗剂，其作为治疗或预防代理用于CRF被认为参与的疾病，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、脑梗死、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、癫痫、皮肤炎、精神分裂症、疼痛等疾病具有有效性。以下式[I]所代表的吡咯吡嘧啶衍生物具有高亲和力对CRF受体，并对CRF被认为参与的疾病具有有效性。
• PYRROLOPYRIMIDINE DERIVATIVES
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：EP1725562A1

  公开（公告）日：2006-11-29
• Pyrrolopyrimidine Derivatives
  申请人：Bischoff P. Francois

  公开号：US20070270588A1

  公开（公告）日：2007-11-22

  According to the present invention, there is provided an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastro-intestinal diseases, drug dependence, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine derivative represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  根据本发明，提供了一种CRF受体拮抗剂，作为治疗或预防CRF参与的疾病的药物，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、高血压、胃肠疾病、药物依赖、脑梗塞、脑缺血、脑水肿、头部外伤、炎症、免疫相关疾病、斑秃、肠易激综合征、睡眠障碍、癫痫、皮炎、精神分裂症、疼痛等。以下式[I]所表示的吡咯吡嘧啶衍生物对CRF受体具有高亲和力，并对CRF参与的疾病有效。